FA Penicillinase resistants

Question 1

Penicillinase-resistant penicillins? nereikia beta-lact inhibitoriu (sulbaktamo, klavulano)

Answer 1

Dicloxacillin, nafcillin, oxacillin

Question 2

Dicloxacillin, nafcillin, oxacillin. mechanism?

Answer 2

same as penicillins

Question 3

Dicloxacillin, nafcillin, oxacillin. spectrum?

Answer 3

narrow

Question 4

Dicloxacillin, nafcillin, oxacillin. Why they are resistant to penicillinase?

Answer 4

resistant because bulky R-group blocks access of beta-lactamase to beta-lactam ring.

Question 5

Dicloxacillin, nafcillin, oxacillin. Clinical use?

Answer 5

S aureus (except MRSA)

Question 6

What for MRSA?

Answer 6

Vancomycin, tigecycline (glycylcyclines), ceftaroline (5th generation cephalosporin), doxycycline (tetracyclines), daptomycin, linezolid

pagal UW: Treatment of MRSA therefore requires a non–beta-lactam medication such as trimethoprim-sulfamethoxazole, clindamycin, doxycycline, or vancomycin.

Question 7

Dicloxacillin, nafcillin, oxacillin. adverse?

Answer 7

hypersensitivity, interstitial nephritis

Question 8

Kas sukelia hypersensitivity?

Answer 8

Metabolitas peniciloine rugstis (haptenas)