FA 1st and 2n cephalosporins

Question 1

1st generation agents? 2

Answer 1

cefazolin and cephalexin

Question 2

2nd generation agents? 4

Answer 2

cefaclor, cefoxitin, cefuroxime, cefotetan

Question 3

cefazolin generation?

Answer 3

1st generation

Question 4

cephalexin generetion?

Answer 4

1st generation

Question 5

cefaclor generation?

Answer 5

2nd generation

Question 6

cefoxitin generation?

Answer 6

2nd generation

Question 7

cefuroxime generation?

Answer 7

2nd generation

Question 8

cefotetan generation?

Answer 8

2nd generation

Question 9

1st generation cover what?

Answer 9

gram + cocci; proteus mirabilis; e coli; klebsiella pneumonia.

Question 10

cefazolin used when?

Answer 10

i/v; prior to surgery to prevent S aureus wound infection.

Question 11

kodel 1st generation netinkama meningitui?

Answer 11

does not cross BBB

Question 12

1st generation and renal function?

Answer 12

in renal failure - netinkami

Question 13

1st generation on pseudomonas?

Answer 13

does not cover

Question 14

1st generation spektras?

Answer 14

siauras

Question 15

2nd generation cover what?

Answer 15

gram +, h influenza, enterobacte aerogenes, neisseria spp., Serratia marcescens, Proteus mirabilis, klebsiella pneumonia

Question 16

2nd generation and renal function?

Answer 16

in renal failure - netinkami

Question 17

2nd generation on pseudomonas?

Answer 17

does not cover

Question 18

kodel 2nd generation netinkama meningitui?

Answer 18

does not cross BBB

Question 19

cephalexin administration?

Answer 19

p/os

Question 20

cefazolin administration?

Answer 20

im, iv

Question 21

cefaclor administration?

Answer 21

p/os

Question 22

cefuroxime administration?

Answer 22

p/os, i/v

Question 23

cefoxitin administration?

Answer 23

i/v

Question 24

cefotetan administration?

Answer 24

i/v

Question 25

which generation is more effective against gram + cocci?

Answer 25

1st stronger than 2nd

Question 26

adverse of all cephalosporins?

Answer 26

hypersensitivity, autoimmune hemolytic anemia;
disulfiram-like reaction; vit K def; Low rate of cross-reactivity ee in penicillin-allergic patients; Increase nephrotoxicity of aminoglycosides.

Question 27

cephalosporins mechanism of resistance?

Answer 27

inactivated by cephalosporinases (a type of beta-lactamase); Structural change in penicillin binding proteins (transpeptidases).