FA Penicilin G, V, amoxicillin, ampic, antipseudomonals

Question 1

Penicilinas G formos?

Answer 1

I/m and I/v

Question 2

Penicilinas V formos?

Answer 2

p/os

Question 3

Penicilinas G ir V - prototype beta lactam antibiotics

Answer 3

.

Question 4

Penicilinas G ir V. Mechanism?

Answer 4

panasus i vankomicino.
D-Ala-D-Ala structural analog. Bind penicilin-binding proteins (TRANSPEPTIDASES).
Block transpeptidase cross-linking of peptidoglycan in cell wall.

Question 5

What group of enzymes activate Penicilinas G ir V?

Answer 5

activate autolytic enzyme

Question 6

Penicilinas G ir V mostly for what bugs?

Answer 6

mostly for gram + (s. pneumonia; s.pyogenes; actinomyces)

Question 7

Penicilinas G ir V for what gram - bugs?

Answer 7

mostly for gram - cocci - N. meningitidis.

Question 8

Penicilinas G ir V for what bugs apart gram + and - ?

Answer 8

spirochetes - mainly treponema pallidum.

Question 9

Penicilinas G ir V. cidal ir static?

Answer 9

bactericial for gram + coci. gram+ rods, gram - cocci, spirochetes.

Question 10

Penicilinas G ir V. relation to beta lactamase?

Answer 10

beta lactamase sensitive.

Question 11

Penicilinas G ir V. adverse?

Answer 11

hypersensitivity, direct Coombs positive hemolytic reaction, drug induced interstitial nephritis.

Question 12

Penicilinas G ir V. resistance mechanism?

Answer 12

beta-lactamase cleaves the beta-lactam rings. Mutations in PBPs.

Question 13

Penicillinase-sensitive penicilins?

Answer 13

Penicilinas G ir V;
Ampicillin;
Amoxicillin

Question 14

what are aminopenicilins?

Answer 14

Ampicillin; Amoxicillin

Question 15

Ampicillin; Amoxicillin - what mechanism?

Answer 15

Same as Penicilinas G ir V

Question 16

what penicillinase precautions for Ampicillin; Amoxicillin?

Answer 16

To protect against destruction by beta-lactamase combine with:
amoxicillin - CLAVULANIC ACID (clavulanate)
Ampicillin - SULBACTAM

Question 17

general Clinical use of Ampicillin; Amoxicillin?

Answer 17

extended-spectrum penicillins

Question 18

Abbcreviation of Clinical use of Ampicillin; Amoxicillin?

Answer 18

HHELPSS - H-influenzae, H pylori, E.coli, Listeria monocytogenes, Proteus mirabilis, Salmonella, Shigella (only ampicillin)
+ enterococci.

Question 19

in H pylori eradicaition?

Answer 19

amoxicillin (if allergy –> metronidazole)

Question 20

Ampicillin; Amoxicillin - in otitis media, sinusitis, UTI, H pylori, VKT?

Answer 20

Amoxicillin

Question 21

Ampicillin; Amoxicillin - meningitis, sigelioze, GI tract (E coli, salomenla, shigela, proteus, enterococus)

Answer 21

Ampicillin

Question 22

Ampicillin; Amoxicillin adverse?

Answer 22

Hypersensitivity, rash (nealerginis berimas), pseudomembranous colititis (ampicilinas, nes used for GI infections), maksties kandidoze

Question 23

Ampicillin; Amoxicillin resistance mechanism?

Answer 23

same as penicillin G and V - penicillinase (a type of beta-lactamase) cleaves beta-lactam rings.

Question 24

What are antipseudomonal penicillins agents?

Answer 24

piperacillin, ticarcillin.

Question 25

what precautions use with antipseudomonal penicillins?

Answer 25

add beta-lactamase inhibitors, because these penicillins are penicillinase sensitive.

Question 26

antipseudomonal penicillins mechanism?

Answer 26

same as penicillin. ecxended spectrum

Question 27

prescribtion of antipseudomonal penicillins?

Answer 27

i/v, salinami per inkstus.

NEREABSORBUOJAMI SKRANDYJE

Question 28

piperacillin, ticarcillin combination with what beta-lactamase inhibitors?

Answer 28

piperacillin - tazobactam

ticarcillin - clavulanate

Question 29

piperacillin, ticarcillin clinical use?

Answer 29

Pseudomonas spp. and gram - rods.

Question 30

piperacillin, ticarcillin. Which one affect klesiella?

Answer 30

piperacillin - veikia

ticarcillin - neveikia

Question 31

piperacillin, ticarcillin. adverse?

Answer 31

hypersensitivity –> maculopapular rash, angioedema, anaphylaxis,

Question 32

What are 4 beta lactamase inhibitors?

Answer 32

Clavulanic acid, avibactam, sulbactam, tazobactam.

Question 33

when added beta lactamase inhibitors?

Answer 33

added to penicilincs to protect them from destruction by beta-lactamase.

Question 34

ampicillin + beta lactamase inhibitor?

Answer 34

ampicllin + sulbactam

Question 35

amoxicillin + beta lactamase inhibitor?

Answer 35

amoxicillin + clavulanate acid

Question 36

ceftazidime + beta lactamase inhibitor?

Answer 36

ceftazidime + avibactam

Question 37

piperacillin + beta lactamase inhibitor?

Answer 37

piperacillin + tazobactam