Viruses (DOLT) Flashcards

1
Q

commonality between viruses and bacteria

A

affect on human health

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2
Q

living or non-living

A

some believe they are living but they don’t meet all the requirements to be considered living organisms

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3
Q

size

A

discovered around 100 years ago because they are so small. around 1/100th size of bacteria

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4
Q

where are they found?

A

every ecosystem

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5
Q

structures

A

interior- long strand of genetic material
extensions- allow viruses to attach to other cells
some have an additional coating made up of lipid molecules

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6
Q

genetic material

A

DNA or RNA surrounded by protective coat of protein

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7
Q

structural shapes

A

helical
circular
polyhedral- multisurfaced
complex

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8
Q

internal organelles

A

no internal organelles

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9
Q

energy

A

no mitocondria or chloroplasts

can’t create or use energy

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10
Q

protein synthesis

A

no ribosomes

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11
Q

cytoplasm

A

no

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12
Q

consumption and excretion

A

don’t consume anything or produce any waste

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13
Q

motility

A

not motile

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14
Q

virus structures

A

surface proteins, capsid, genetic material, viral envelope

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15
Q

classification

A

shape, type of genetic material, or type of organism/tissue they infect

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16
Q

bacteriophages “phages”

A

viruses that can infect bacteria and kill them

useful in search for vectors for genetic engineering

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17
Q

Felix D’Herelle

A

Canadian scientist
discovered phages
researched ways to cholera and typhoid with viruses
research halted when penicillin was discovered

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18
Q

viral reproduction

A

can only reproduce inside a living host/cell

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19
Q

infected by a virus

A

virus is inside your cells and reproducing to create more viruses and infect more cells
create a “virus factory”- cells can no longer perform their usual functions
last step in reproduction is splitting the cell open and releasing 1000s of new viruses

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20
Q

ways for a virus to enter a cell

A
  1. cell engulfs virus like an amoeba engulfs its food
  2. protein layer of virus fuses with the host cell’s membrane
  3. DNA viruses- inject genetic material into cytoplasm
  4. RNA viruses- have an enzyme that converts RNA to DNA then injects it into cytoplasm
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21
Q

reproduction cycles

A

lytic and lysogenic

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22
Q

lyric cycle

A

actively causing a disease
starts when virus is engulfed into host cell or fuses to it
viral DNA becomes part of host DNA and host used its own enzymes to help viruses reproduce
host’s ribosomes make protein for viruses
cycle continues as viruses continue to be engulfed or fuse

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23
Q

making a new virus

A

protein and DNA is assembled during lytic cycle

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24
Q

lyses

A

when a cell splits open because it is too full of viruses

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25
lysogenic cycle
not actively causing a disease turns into lytic cycle when environmental factors trigger DNA into taking control of the cell after DNA is injected into the host cell nothing happens during the lysogenic cycle
26
examples of viral diseases
common cold, influenza (flu), measles, mumps, rhubella, chicken pox, hepatitis, rabies, polio, small px, HIV
27
vulnerability factors for viral diseases
very young, elderly, imunocompromised people, people who are already sick
28
least vulnerable
healthy young-middle aged adults
29
recovery from viral diseases
depends on virus some are more dangerous than others vulnerability factors affect the seriousness of it and the likelihood of recovery
30
childhood diseases
exception to vulnerability factors much more serious for adults than children adult males can become sterile because of mumps ex. mumps. measles, chicken pox
31
ways to spread viral diseases
airborne, bodily fluids, touch
32
spread airborne
coughing and sneezing | breathe the viruses in
33
spread through bodily fluids
blood, saliva, urine, semen sharing food and drinks ex. STDs
34
spread through touch
rubbing eyes after touching something that has a virus on it | open cuts or sores
35
lifetime outside of a living host/cell
not very long | rely on their host to survive
36
mechanical barriers
first line of defense against both viral and bacterial diseases skin, nose, tears
37
skin
unbroken skin blocks disease | broken skin provides a way for diseases to enter the body
38
nose
lined with cilia that use mucus to trap incoming viruses | sneeze when there is a build-up of mucus which gets rid of the viruses
39
tears
salty- creates an unfavourable environment | when eyes are irritated they become watery and wash the irritant away
40
second line of defense against disease
cellular
41
white blood cells
converge at site of infection and engulf bacteria or viruses | die when they are too many inside them
42
lysosomes
destroy bacteria or viruses with an enzyme after white blood cell engulfs it
43
pus
mix of dead white blood cells, viruses and bacteria
44
histamines
cause swelling and redness | cells near infection release histamines to dialate blood vessels- increase supply of white blood cells
45
allergic reactions
cause cells to release histamine | anti-histamines counter it
46
Helper T cells
produced by thymus gland (located under sternum) | direct the immune system response
47
Killer T cells
released from thymus gland by Helper T cells | kill cells infected with viruses to prevent them from splitting
48
B cells
Helper T cells activate 2 types: plasma and memory 'b' stands for bone marrow responsible for immunity fevers help produce them
49
Suppressor T cells
returns body back to normal after infection
50
interferon
protein released by cells interacting during an infections speed up action of T cells and B cells Human Interferon is produced by genetic engineering
51
antibodies
final line of defense y shaped molecules attach to viruses and destroy them can prevent viruses from infecting more cells
52
antigens
projections on viruses that antibodies use to connect to them
53
production of antibodies
produced by plasma B cells
54
memory B cells
"remember" antigens | produce the correct antibodies immediately
55
immunity
means you will not contract a certain disease | different types: genetic or exposure
56
immunity in babies
get antibodies from their mothers through the placenta and breast feeding lose their immunity because memory B cells aren't created and antibodies don't last for a long time
57
injections of antibodies
temporary immunity done during epidemics for medical personnel and essential service workers isolated from donated blood
58
permanent immunity
2 ways: 1. having the disease: memory B cells are created as your body fights the illness 2. vaccines: trick the body into believing its had the disease and creates memory B cells
59
vaccines
injections of dead or weakened viruses only effective if virus doesn't change or mutate sometimes feel a little ill after getting one
60
Edward Jenner
discovered the first vaccine in 1796 | injected cow pox into a child and then small pox after the child recovered and the child did not develop small pox
61
not being vaccinated
some people are opposed to them based on religious, safety, personal choice, and ethical grounds some people can be allergic to the eggs used to create vaccines (tend to be other options available) fewer people vaccinated=higher risk of epidemic
62
link between vaccines and autism
published by Andrew Wakefield in 90s many children were no vaccinated in response 2011- Wakefield lost his license for falsifying the research (too late for many children) 2019- many epidemics of measles in different countries
63
the flu
airborne RNA virus spreads across the world every year and varies in severity symptoms: chills, fever, muscle and joint pain, headache, coughing, runny nose, sore throat sunlight, detergents and disinfectants kill it
64
vaccine for the flu
based on the WHOs prediction of what strains will be present in the next year some years it is more accurate than others takes 2 weeks to take effect
65
what the flu infects
birds and mammals (not just humans) | cross from one species to another through mutation
66
Spanish flu
1918-19 after WWI most severe flu outbreak ever reported "Spanish" because Spain reported the most openly about the symptoms and severity ~100mil people were killed (more than in the war) killed the young-middle aged healthy adults caused overactivity of immune system
67
H1N1 virus
2009 outbreak better controlled ~300.000 deaths
68
HIV
human immunodeficiency virus causes AIDS (acquired immunodeficiency syndrome)- disease in the human immune system transmitted through blood, unprotected sex, placenta, childbirth, breast feeding, contaminated needles, blood transfusions not transmitted through saliva or tears, or other bodily fluids RNA virus- can undergo a lysogenic cycle and remain dormant for years attacks Helper T cells people with AIDS have lowered immune system no cure or vaccine
69
ARVs
slow progress of HIV/AIDS and increase life expectancy very expensive required for the rest of the person's life many side effects