viruses and vaccinations Flashcards
which specific ig can be injected for passive immunity
gamma globulin
fever definition
> 37.8
which cell is the only cell which can ctivate naive T cell
dendritic cell
where do most memory T cells live
tissue
what increases immunogenicity of vaccines that contain inactivated antigens
vaccine adjuvant
who can’t have attenuated vaccine
immunosuppressed- danger of infectino
only viral vector vaccine
ebola
what pathogens cause meningitis at different ages
which vaccine type provides best protection
live attenuated
which ig is released first
IgM
which antibody can only be
childhood immunity schedule
Diphtheria, tetanus, pertussis, polio, Haemophilus influenzae type b and hepatitis B
8 weeks
12 weeks
16 weeks
Diphtheria, tetanus, pertussis and polio
3 years 4 months
Tetanus, diphtheria and polio
14 years
what are infants very bad at mounting immune response against and what is the solution
polysaccharides - conjugate with a peptide
what does rotavirus vaccine protect against specifically
serious disease
what is interesting about measles vax
can be administered after infection to help recovery
calculation for herd immunity
1-1/R0
what does R0 mean
basic reproduction number of a disease
cholera and diphtheria and C diff produce
exotoxins
what is this illlness and what can you see
diphtheria, pseudomembrane
how does diphtheria toxin works
inhibits protein synthessi
cytokines implicated in sepsis at he beginning
IL-6, TNF-alpha
eustachian tube in infant is..
more horizontally orientated
which chemo med for sickle cell, how does it help
Hydroxycarbamide/hydroxyurea (same thing), increases HbF
who is predisposed to pneumococcal infection and what do you give them
Absent / non-functional spleen
Congenital asplenia
Traumatic removal
Hyposplenism (eg sickle cell)
Hypogammaglobulinaemia
HIV infection
give PPV pneumococcal Polysaccharide vaccine
why treat otitis media promptly
can spread to meninges
what is empyema
pus-filled pockets that develop in the pleural space.
which children susceptible to mould/yeast sepsis
very premature or under tx for leukaemia
which causes worst form of malaria and what is the proble
P. falciparum - cerebral malaria
severe malaria in children symptoms (4)
Anaemia
Respiratory distress
Cerebral malaria (coma, seizures)
Hypoglycaemia
tx for congenital CMV - how does it work
IV ganciclovir or oral valganciclovir (pro-drug) – inhibits DNA synthesis
Epstein-Barr associated with what malignancy esp in Africa
Burkitt’s Lymphoma
