gp2 Flashcards
red flags for cough
night sweats, unexplained weightloss, prolonged cough
massive baby in utero is called
macrosomia
how would you discover disproportionate short stature
do sub ischial standard deviation - sitting standard deviation
which gene leri weill
SHOX
which bones leri weill
radius/ulna
tibia/fibula
where is shox gene situation
on both X and Y
what is this defformity
Madelung (short stature) deformity don’t fit properly together
causes of disproportionate short stature (4)
achondroplasia
hypochondroplasia
ricketts
Leri Weill dyschondrosteosis
when are most girls with Turner diagnosed
adulthood
all girls with short stature need a…
karyotype analysis
GH is secreted in what style
pulsatile
GH biggest peak
deep sleep
GH deficiency characterised by
decrease of velocity (plateauing) of growth
GH deficiency length at birth
normal or only slightly reduced
do you use oxandrolone for GH deficiency? what is it
no. anabolic steroid
growing tx for Turner’s
oxandrolone
definition of delayed puberty
have not reached Tanner stage 2 by 13 in girls and 14 in boys
what drug to block puberty
GNRH - desensitising
from which stage is puberty irreversible
Tanner stage 3
risk allele for alzheimers
ApoE4
what is Laron syndrome
GH signalling broken, tiny patients who don’t age
what is mTor pathway
anabolic pathway to produce protein
which hormones are released by muscle to stimulate brain neurogenesis
irisin, cathepsin beta
metformin blunts what physiological advantage
muscle hypertrophy and mitochondrial advantages
mediator of broken heart syndrome
cortisol
what sort of drug currently in clinical trials can wipe out senescent cells
senolytics
