Virology Exam 2 - Herpesvirus

Question 1

general structure of herpesvirus
small/large
enveloped/non-enveloped
shape
DNA/RNA

Answer 1

large, lipid, pleomorphic, glycoproteins, tegument
enveloped
icosahedral nucleocapsid
linear dsDNA

Question 2

life cycle of herpesvirus

Answer 2

1. large linear dsDNA encodes 70-200 proteins
2. nucleus replication
3. infection consists of complicated lytic infection, latent/persistent infection and reactivation/recrudescence

Question 3

role of latency in herpesvirus infection

Answer 3

increase epigenetic silencing
increase mRNA silencing
decrease apoptosis
increase neuronal survival

latency-associated transcripts (LAT)

Question 4

alphaherpesviridae
host range:
disease:
replication type:
cytopathic effect:
latency location:

Answer 4

restricted natural host range
severe disease compared to other herpesviruses
rapid replication and tissue lysis
rapid cytopathic effect in cell culture
sensory ganglia & lymphoid tissue

Question 5

betaherpesviridae
host range:
replication type:
cytopathic effect:
latency location:

Answer 5

highly restricted host range
slow replication
cytomegalia in cells
secretory gland, lymphoreticular cells, kidneys

Question 6

gammaherpesviridae
host range:
replication type:
cytopathic effect:
latency location:

Answer 6

restricted host range
lymphoblastoid (T/B ) cells, some viruses cause oncogenic transformation
lytic infections in epithelioid and fibroblastic cells
lymphoid tissue

Question 7

Suid Herpesvirus
FAMILY
ETIOLOGIC AGENT
HOST
CLINICAL SIGNS

Answer 7

betaherpesviridae
suid herpesvirus 2 & porcine cytomegalovirus
pigs
atrophic rhinitis, stillbirths if infected during pregnancy

Question 8

Alcelaphine Herpesvirus 1
FAMILY
ETIOLOGIC AGENT
HOST/RESERVOIRS
TRANSMISSION
CLINICAL SIGNS

Answer 8

gammaherpesviridae
AHV1
cattle, deer, and antelope (affected)
wildbeest, topi, hartebeest (reservoirs)
wildbeest or calves
malignant catarrhal fever

Question 9

Ovine Herpesvirus 2
FAMILY
ETIOLOGIC AGENT
HOST/RESERVOIRS
TRANSMISSION
CLINICAL SIGNS

Answer 9

gammaherpesviridae
OHV2
cattle, deer, BISON (affected)
domestic sheep (reservoirs)
sheep
malignant catarrhal fever

Question 10

presentation of malignant catarrhal fever

Answer 10

sporadic fatal disease
mucopurulent discharge
keratoconjunctivitis with corneal opacity
lymphadenopathy
vasculitis, immunopathologic lesion
gastroenteritis, ulceration, hemorrhage

Question 11

Gallid Herpesvirus-1
ETIOLOGIC AGENT
HOST
DISEASE

Answer 11

GHV1, infectious laryngotracheitis virus (ILTV); multiple strains
4-18mo chickens
infectious laryngotracheitis

Question 12

Gallid Herpesvirus-2
ETIOLOGIC AGENT
HOST
DISEASE
PATHOGENESIS

Answer 12

GHV2; 3 serotypes (1 - oncogenic viruses in chickens, 2- - avirulent chicken virus, 3 - avirulent turkey virus)
12-24 wk chickens
Marek’s Disease - neurolymphomatosis, visceral lymphoma, ocular lymphomatosis, cutaneous Marek’s Disease
“onc” genes

Question 13

Psittacine Herpesvirus 1
ETIOLOGIC AGENT
HOST
DISEASE
CLINICAL SIGNS

Answer 13

PHV1 & PHV2,3
Psittacines
Pacheco’s disease (PHV1)
PD-like disease viruses (PHV2,3)
sudden death, GI, resp, CNS

Question 14

bovine herpesvirus 1 (BHV1)
ETIOLOGIC AGENT
HOST
DISEASES
TRANSMISSION
PATHOGENESIS

what is this a component of?

Answer 14

BHV1
bovine, wild ruminants
infectious bovine rhinotracheitis (IBR), red nose, necrotic rhinitis/tracheitis, conjunctivitis, keratosis, corneal ulcers, infectious pustular vulvovaginitis, balanoposthitis,abortions, neonatal disease
- systemic dz associated w/ encephalitis & abortion
venereal
replicated in epithelial cells

component of BRD complex “shipping fever”

Question 15

BHV5
HOST
DISEASE

Answer 15

domestic cattle
herpesviral meningoencephalitis

Question 16

equine herpesvirus 1 & 4
ETIOLOGIC AGENT
HOST
DISEASE
PATHOGENESIS

Answer 16

EHV1 or 4
equine
equine rhinopneumonitis & abortion (1 & 4)
neurologic disease - encephalomyelitis/opathy (EHV1)
point mutation in polymerase gene

Question 17

equine herpesvirus 3
ETIOLOGIC AGENT
HOST
DISEASE
TRANSMISSION
PATHOGENESIS

Answer 17

EHV3
equine
equine coital exanthema, herpesviral venereal disease, acute herpetic infection, depigmentation
venereal/iatrogenic
temperature restricted viral replication

Question 18

caprine herpesvirus 1
ETIOLOGIC AGENT
HOST
DISEASE
TRANSMISSION

Answer 18

CapHV1
goats
neonatal mortality, abortions, vulvovaginitis, balanoposthitis
venereal/transplacental

Question 19

Pseudorabies Virus
ETIOLOGIC AGENT
HOST
DISEASE
PATHOGENESIS

present in US?

Answer 19

porcine herpesvirus 1 (PHV1)
swine (reservoir host)
dogs, cats, ruminants, raccoons, rodents (secondary host)
Pseudorabies, Aujeszky’s disease (abortions, resp, GI, neuro)
swine - meningoencephalitis
2 host - mad itch, CNS, fatal
replicates in respiratory tract, then PNS latency in trigeminal ganglion, replicates in LN and viremia, secondary replication in placenta

no, eradicated in US

Question 20

feline herpesvirus 1
ETIOLOGIC AGENT
HOST
DISEASE

Answer 20

FHV1
felines
respiratory disease, ocular disease, neonatal mortality

Question 21

canine herpesvirus 1
ETIOLOGIC AGENT
HOST
DISEASE

Answer 21

CHV1
canines < 4 wk age
turkey egg kidney, GI, resp, neonatal mortality, ocular, repro