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virology Flashcards

1
Q

Adenovirus

A

Shed from eyes/respiratory secretions

Pneumonia in children, respiratory distress, diahrrea

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2
Q

HSV-1

A

Herpesviridae
dsDNA
Spread through contact with secretions
Oral Herpes

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3
Q

HSV-2

A

Herpesviridae
dsDNA
Spread through secretions
Genital Herpes, neonatal, encephalitis

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4
Q

Cytomegalovirus (CMV)

A 
Herpesviridae
Slow replication
spread though contact
Shed in saliva, tear, breast milk,urine
Asymptomatic or Infectious-Mono-like
petichae, hepatosplenomegaly
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5
Q

Epstein-Barr Virus

A

Herpesviridae
Infectious Mononucleosis (sore throat, fever, lymphadenopathy)
Increased age = increased symptoms
Diagnosed though serological test

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6
Q

Variella Zoster Virus (VZV)

A

Herpesviridae
Droplet inhalation or contact with lesions
Varicella = chickenpox (children, heals in 1-2 weeks)
Zoster = Shingles (adults, remains latent in cranial ganglia after primary infection; rashes, lesions, pain)

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7
Q

Human Herpesvirus-6

A 
Herpesviridae
Roseolla
children 6months-2 years
fever, rash
reactivation in immunocompromised people
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8
Q

Papillomas/warts

A

Papviridae
High Rick= Type 16, 18
Diagnosis in cytology

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9
Q

Variola (Small Pox)

A

Poxviridae

rash, fever, lesions on palms/head/soles

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10
Q

Parvovirus

A 
Parvoviridae
Smallest DNA virus
more common in children
"slapped face" rash for up to 2 weeks
decreased RBCs (short lived anemia)
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11
Q

Rotavirus

A 
Reoviridae
most viral gastroenteritis in kids
spread through oral-fecal route
Replicates in epithelial cells of microvilli of small intestine, virus shed in stool
vomit, diarrhea, fever
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12
Q

Coltivirus

A

Reoviridae

Colorado Tick Fever (Dengue-like)

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13
Q

Lassa Virus

A

Arenaviridea
Asymptomatic OR diarrhea/vomiting (hemorrhaging if advanced)
Spread though contact with excretions from rats

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14
Q

Rift Valley Fever Virus

A

Bunyviridae
Arthropod vector
encephalitis/hepatitis

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15
Q

Hanta Virus

A

Bunyviridea

Hemorrhagic fever with renal syndrome

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16
Q

Coronavirus

A 
Coronaviridae
RNA virus
Cold-like symptoms
fever, pneumonia
SARS
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17
Q

Ebola Virus

A

Filoviridae
High mortality
Fever, chills, diarrhea, vomit, hemorrhaging of organs

18
Q

Dengue

A 
Flaviviridea
Transmitted by mosquitoes
Fever, bone pain ("Break Bone Fever")
Self-limiting (1-2 wks)
DHF = hemorrhage, shock
19
Q

Influenza Virus

A

Orthomyxoviridea
Enveloped with 8 segments of ssRNA
Surface Ag “H” (hemagglutanin) is used to bind to host cells
Vaccination contains 2 strains of Flu A and 1 strain of Flu B (trivalent)
Droplet spread

20
Q

Antigenic Drift

A

minor change in antigenic structure

21
Q

Antigenic Shift

A

drastic change in antigenic structure

22
Q

Genetic reassortment

A

when coinfected with BOTH Avian and human influenza = new strain

23
Q

Rubulavirus

A

Paramyxoviridea
ssRNA
MUMPS
spread through droplets

24
Q

Morbillivirus

A 
Paramyxovirdea
Measles (rubeola)
Spread by aerosols
Resp. tract, lymph nodes
Sneezing, coughing, fever
"Koplik Spots" (Oral lesions)
25
Q

RSV

A

Pneumoviridea
Croup, Bronchitis
infants, nosocomial
droplets/fomites

26
Q

Enterovirus

A

Picornaviridea
In areas of poverty/poor hygiene
Aerosol/fomite
nausea, diarrhea

27
Q

Poliovirus

A

Picornaviridea

Polio

28
Q

Coxsackivirus

A 
Hand Foot and Mouth Disease
Picornaviridae
Fomites, fecal-oral
naked viruses
sores on tongue/soft palette
rash on hands/feet
29
Q

Rhinovirus

A

Picornaviridea
small, naked
common cold
aerosols
grows best on human diploid fibroblast cells
Differentiated from Enterovirus with acid buffed (Rhinovirus is acid LABILE, Enterovirus is acid STABLE)

30
Q

HIV

A 
Retroviridae
ssRNA
spherical virus with 3-layer structure
blood/body fluids
life cycle: Targets CD4+ T Cells, mild symptoms, latency period (while virus is reproducing), decreased lymphocytes, swollen lymph nodes, opportunistic infections occur (cancer, histo, toxo)
Confirm with Western Blot
31
Q

Rhabdoviridae

32
Q

Hepatitis A

A 
Naked ssRNA
Picornaviridea
Fecal-oral route
Virus replicates in liver cells, passes into intestine, shed in stool
Does NOT cause chronic liver damage
33
Q

Hepatitis B

A 
Hepadnavirus
enveloped ssDNA
Blood-borne, semen, vaginal fluid
transmitted sexually and pernatal
IV drug abusers
Fever, hepatic tenderness, jaundice
Can lead to carcinoa/cirrhosis
HBsAg = HBV
34
Q

Hepatitis C

A

Flaviviridae
ssRNA
blood transfusions, IVDA
cirrhosis/hepatic carcinoma

35
Q

Hepatitis D

A

Deltavirus
ssRNA
Needs HBV (co-infection)

36
Q

Hepatitis E

A

ssRNA

Fecally contaminated water

37
Q

HBsAG

A

late incubation and acute

38
Q

Anti- HBs

39
Q

Anti- HBc IgM

A

Acute and Convalescent

40
Q

Anti-HBc Total

A

Acute, Convalescent, and recovery

SM (16 decks)

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