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Micro > Virology > Flashcards

Virology Flashcards

1
Q

Are DNA viruses double or single stranded and what is the exception

A

All are double stranded DNA - except Parvoviridae

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2
Q

What DNA viruses are circular and which are linear

A

All are linear, except Papilloma, Polyoma, and Hepadna, which are circular

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3
Q

What is the genomic structure of RNA viral genome

A

All RNA viruses are single stranded RNA except Reoviridae

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4
Q

What RNA viruses are positive stranded

A 
Retrovirus
Togavirus
Flavivirus
Coronavirus
Hepevirus
Calicivirus
Picornavirus
(Retro toga party where I drank flavored coronas and ate hippy california pickles)
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5
Q

What is the difference between positive and negative stranded RNA

A

Positive strand = like mRNA and can translate directly

Negative strand = must transcribe before translating

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6
Q

What naked viral genomes are infectious?

A

Most dsDNA viruses (except pox and HBV)

Positive stranded ssRNA (=mRNA)

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7
Q

What naked viral genomes are not infectious

A

Negative strand ssRNA
dsRNA
They require polymerases that are part of a complete virion

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8
Q

Where do DNA viruses replicate, and what is the exception

A

All replicate in nucleus except poxvirus

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9
Q

Where do RNA viruses replicate and what is the exception

A

All replicate in cytoplasm except influenza and retrovirus

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10
Q

What are the naked viruses?

A 
Papilloma
Adeno
Parvo
Polyoma
Calici
Picorna
Reo
Hepe
(Give PAPP smears and CPR to a naked Heppy)
DNA = PAPP; RNA = CPR and hepe
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11
Q

Where does herpesvirus get its envelope

A

Unlike other enveloped viruses that get their envelope from plasma membrane when exiting, herpesvirus gets its from the nuclear membrane

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12
Q

Which DNA viruses are naked

A 
PAPP
Papilloma
Adeno
Parvo
Polyoma
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13
Q

Which RNA viruses are naked

A 
CPR + hippy
Calici
Picorna
Reo
Hepe
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14
Q

Where does Pox virus replicate

A

Pox is the only DNA virus not to replicate in the nucleus - it replicates in the cytoplasm because has own DNA-dependent RNA polymerase

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15
Q

What is the structure of Pox virus

A

Unlike all other DNA viruses that are icosahedral, pox has a complex structure

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16
Q

What are the DNA viruses?

A 
They are HHAPPPPY viruses:
Hepadna
Herpes
Adeno
Pox
Parvo
Papilloma
Polyoma
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17
Q

Name all of the herpesviruses

A

HSV-1, HSV-2, VZV, EBV, CMV HHV-6 (Roseola), HHV-7, HHV-8 (Kaposi)

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18
Q

What is the structure of all herpes viruses

A

Enveloped, DS and linear

19
Q

What medical condition does hepadnavirus cause

A

HBV

20
Q

What is the structure of hepadna virus

A

Partially DS and circular

21
Q

What virus is not a retrovirus but contains reverse transcriptase

A

HBV-hepadnavirus

22
Q

What is the structure of adenovirus

A

DNA virus, nonenveloped, DS and linear

23
Q

What medical conditions does adenovirus cause

A

Febrile pharyngitis
Acute hemorrhagic cystitis
Pneumonia
Conjuntivitis

24
Q

What is the structure of parvovirus

A

DNA virus, naked and SS (only DNA virus that is SS), linear (-)

25
Q

What is the smallest DNA virus

A

Parvovirus

26
Q

What is the structure of papillomavirus

A

Non-enveloped DS and circular DNA

27
Q

What medically important viruses does polyomavirus include

A

JC virus, BK virus (transplant patients, targets kidney)

28
Q

What is the BK virus

A

Polyomavirus that targets kidney in transplant patients

29
Q

What is the structure of Poxvirus

A

Enveloped DS and linear DNA virus

30
Q

What is the largest DNA virus

A

Poxvirus

31
Q

What virus causes molluscum contagiosum and what is its structure

A

Poxvirus - enveloped linear DS DNA

32
Q

Flesh colored dome lesions with central umbilicated dimple

A

Molluscum contagiosum

33
Q

Which herpes virus causes temporal lobe encephalitis and what is its structure

A

HSV-1, Enveloped DS linear DNA virus

34
Q

Where does HSV-2 reside in latent form

A

Sacral ganglia

35
Q

Where does VZV stay dormant

A

Dorsal root or trigeminal ganglia

36
Q

What is the most common complication of shingles

A

Post-herpetic neuralgia

37
Q

What kind of cells are seen on smear in EBV infection

A

Atypical lymphocytes seen are reactive CD8+ cytotoxic T cells (not infected B cells)

38
Q

In what type of cells does CMV stay latent

A

Mononuclear cells

39
Q

HHV-6

A

Roseola

40
Q

Roseola clinical presentation

A

High fevers for several days (that can cause seizure)

Followed by diffuse macular rash

41
Q

What is Kaposi sarcoma

A

HHV-8 - neoplasm of endothelial cells

42
Q

How is HHV-8 Transmitted

A

Sexual contact

43
Q

Tzanck test

A

Smear of an opened skin vesicle to detect multinucleated giant cells

44
Q

Cowdry A intranuclear inclusions

A

In HSV-infected cells

Micro (8 decks)

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