Viral Pathogenesis

Question 1

LO 1. Explain the effects of tissue tropism, virulence, and the host responses on the nature of viral disease.

Answer 1

Tropism: certain viruses have affinity for certain tissues (access, receptors, genes, host defenses present)

Question 2

LO 2. Compare/contrast acute local disease vs. acute systemic disease in incubation periods, virus shedding and transmission, host responses, and likelihood of re-infection.

Answer 2

local = 1-3 days incubation, shedding from site of infection, IgA, short-term immunity only
systemic= 10-21 days incubation, shedding from multiple and/or distant sites, IgG and IgA, lifelong immunity

Question 3

LO 3. Describe the expected outcome of viral infection and disease in a healthy host vs. an immune-compromised host, including symptoms, shedding and transmission, and length of primary infection.

Answer 3

healthy =

immunocompromised =

Question 4

LO 4. Detail 2 differences btw persistent and latent infection.

Answer 4

persistent = lasts for longer periods of time, may be result of 1a infection that was not cleared
latent = substantial periods of time in which the host produces no detectable virus

Question 5

LO 5. List the potential outcomes and types of viral diseases with contributing factors.

Answer 5

1. acute local
2. acute systemic
3. chronic/persistent
4. latent
5. slow/progressive