Inflammatory Skin Disease

Question 1

What is xerosis?

Answer 1

dry skin

Question 2

What are the Diagnostic Criteria of Atopic Dermatitis?

Answer 2

Must have: Itchy skin + Plus 3 or more of the following:
o History of involvement of skin creases (or face if pt < 10 yrs)
o Personal history of asthma or hay fever (or FH of atopic disease if pt < 4 yrs)
o History of dry skin within the last year
o Visible flexural eczema (or face)
o Onset under 2 years of age

Question 3

What causes Atopic Dermatitis?

Answer 3

• Barrier disrupted skin
• Filaggrin mutation
• Staphlyococcus aureus acts as a superantigen
• Elevated IgE
• Eosinophilia
• TH2 type cytokine (IL-4, IL-5, IL-10) immune response produced

Question 4

What is irritant contact dermatitis?

Answer 4

Non-immunologically mediated reaction from a single or repeated exposures to an irritant

Question 5

What is an exanthematous eruption?

Answer 5

a drug rash

Question 6

Which drugs cause exanthematous eruptions?

Answer 6

really any drugs, especially:
o Aminopenicillins
o Sulfonamides
o Cephalosporins
o Anticonvulsants
o Allopurinol

Question 7

How are exanthematous eruptions treated?

Answer 7

1. stop offending medication
2. supportive care (should resolve after several weeks-months)
3. topical steroids and antihistamines

Question 8

What is urticaria?

Answer 8

hives/wheals

Question 9

What is the tx for urticarial?

Answer 9

usually self-resolves, but antihistamines and topical steroids ok

Question 10

What is irritant contact dermatitis?

Answer 10

non-immunologically mediated reaction to an irritant; burns more than it itches

Question 11

What is allergic contact dermatitis?

Answer 11

type IV allergic response to previously encountered allergen

Question 12

How is allergic contact dermatitis diagnosed?

Answer 12

patch testing

Question 13

What comorbidities are seen in psoriasis pts?

Answer 13

1. Arthritis
2. Crohn’s disease
3. insulin resistance, obesity and metabolic syndrome
4. atherosclerosis
5. Cardiovascular Disease