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Unit 4: D & D > Benign Neoplasms of the Skin > Flashcards

Benign Neoplasms of the Skin Flashcards

1
Q

What are nevus cell nests present at the dermal epidermal junction and within the dermis called?

A

compound nevi

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2
Q

What mutations are associated with Nevus Sebaceous?

A

HRAS and KRAS

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3
Q

This is a consumptive thrombocytopenic coagulopathy associated with large infantile hemangiomas.

A

Kasabach-Merritt syndrome

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3
Q

What is the difference between an infantile hemangioma and a port wine stain?

A

an infantile hemangioma will self-resolve

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3
Q

What are nevus cells at the dermal epidermal junction just above the basement membrane zone of the epidermis called?

A

junctional nevi

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4
Q

What skin finding is associated with PHACES syndrome?

A

infantile hemangiomas

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5
Q

What germline mutations are associated with FAMM?

A

– CDK2NA mapped to 9p21 – CDK4 mapped to 12q14 – CMM1 mapped to 1p

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6
Q

Infantile hemangiomas will stain with ___.

A

GLUT-1

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7
Q

What is a Acrochordon?

A

a skin tag

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7
Q

What is the tx for dermatofibromas?

A

none, but sample lesion if CA is suspected

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8
Q

What is the tx for Nevus sebaceus?

A

usually none, just observation

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9
Q

SKs are benign, but if the _____ is seen, there might be an underlying adenocarcinoma of the stomach.

A

Sign of Leser-Trelat

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10
Q

What is a characteristic sign of dermatofibromas?

A

dimple sign when pinched

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11
Q

What is a Dermatofibroma?

A

brown, firm papules and usually range from 3-10 mm in size

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12
Q

What is Sturge Weber syndrome (SWS) and which skin finding is it assoc with?

A

a congenital disorder characterized by mental retardation, glaucoma, seizures, and ipsilateral angiomas; port wine stain

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12
Q

Where do junctional nevi occur?

A

nevus cells are at the dermal epidermal junction just above the basement membrane zone of the epidermis

13
Q

What is FAMM syndrome?

A

genetic disorder characterized by numerous nevi (>50) and malignant melanoma in a first degree relative

14
Q

Does a Port Wine Stain stain with Glut-1?

A

Nope

15
Q

What is a Seborrheic keratosis (SK)?

A

oval, slightly raised, light brown to black papules or plaques

15
Q

Name the 3 growth patterns of nevi.

A

– Intradermal nevus – Junctional nevus – Compound nevus

17
Q

This is a disorder characterized by: Posterior fossa malformations Hemangiomas Arterial anomalies of the aortic branches Cardiac defects and coarctation of the aorta Eye anomalies Sternal defects and supraumbilical raphev

A

PHACES syndrome

18
Q

What are nevus cell nests that are exclusively within the dermis called?

A

intradermal nevi

19
Q

A Nevus sebaceus on the scalp is associated with ____.

A

allopecia

20
Q

What mutation is assoc. with Port Wine Stains?

A

GNAQ

22
Q

What is the tx for Sebaceus hyperplasia?

A

none- cosmetic issue only

24
Q

What is Sebaceus hyperplasia?

A

common benign tumor of the oil gland

25
Q

____ will stain with GLUT-1.

A

Infantile hemangiomas

27
Q

Why do you have to watch a Nevus sebaceus?

A

up to 30% transform into epithelial neoplasms

28
Q

Where are Sebaceus hyperplasia found on the skin?

A

face>trunk>extremities

29
Q

Nevi are classified depending on ____.

A

the location of the melanocytic nests

30
Q

What are compound nevi?

A

nevus cell nests are present at the dermal epidermal junction and within the dermis

32
Q

What is Kasabach-Merritt syndrome and what skin finding is it assoc. with?

A

a consumptive thrombocytopenic coagulopathy associated with large infantile hemangiomas

33
Q

What is PHACES syndrome?

A

a disorder characterized by: Posterior fossa malformations Hemangiomas Arterial anomalies of the aortic branches Cardiac defects and coarctation of the aorta Eye anomalies Sternal defects and supraumbilical raphe

34
Q

Muir-Torre syndrome is assoc. with which skin finding?

A

Sebaceus hyperplasia

35
Q

What is a Nevus sebaceus?

A

a papillomatous, yellow-orange linear plaque on the face or scalp

36
Q

What are intradermal nevi?

A

nevus cell nests exclusively within the dermis

37
Q

What is the Sign of Leser-Trelat?

A

sudden onset of multiple SKs associated with adenocarcinoma of the stomach

38
Q

What does a Sebaceus hyperplasia look like?

A

1-6 mm yellowish-white papule (globules) with central dell

39
Q

Where are dermatofibromas usually found?

A

on the legs

Unit 4: D & D (22 decks)

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