Benign Neoplasms of the Skin Flashcards
What are nevus cell nests present at the dermal epidermal junction and within the dermis called?
compound nevi
What mutations are associated with Nevus Sebaceous?
HRAS and KRAS
This is a consumptive thrombocytopenic coagulopathy associated with large infantile hemangiomas.
Kasabach-Merritt syndrome
What is the difference between an infantile hemangioma and a port wine stain?
an infantile hemangioma will self-resolve
What are nevus cells at the dermal epidermal junction just above the basement membrane zone of the epidermis called?
junctional nevi
What skin finding is associated with PHACES syndrome?
infantile hemangiomas
What germline mutations are associated with FAMM?
– CDK2NA mapped to 9p21 – CDK4 mapped to 12q14 – CMM1 mapped to 1p
Infantile hemangiomas will stain with ___.
GLUT-1
What is a Acrochordon?
a skin tag
What is the tx for dermatofibromas?
none, but sample lesion if CA is suspected
What is the tx for Nevus sebaceus?
usually none, just observation
SKs are benign, but if the _____ is seen, there might be an underlying adenocarcinoma of the stomach.
Sign of Leser-Trelat
What is a characteristic sign of dermatofibromas?
dimple sign when pinched
What is a Dermatofibroma?
brown, firm papules and usually range from 3-10 mm in size
What is Sturge Weber syndrome (SWS) and which skin finding is it assoc with?
a congenital disorder characterized by mental retardation, glaucoma, seizures, and ipsilateral angiomas; port wine stain
Where do junctional nevi occur?
nevus cells are at the dermal epidermal junction just above the basement membrane zone of the epidermis
What is FAMM syndrome?
genetic disorder characterized by numerous nevi (>50) and malignant melanoma in a first degree relative
Does a Port Wine Stain stain with Glut-1?
Nope
What is a Seborrheic keratosis (SK)?
oval, slightly raised, light brown to black papules or plaques
Name the 3 growth patterns of nevi.
– Intradermal nevus – Junctional nevus – Compound nevus
This is a disorder characterized by: Posterior fossa malformations Hemangiomas Arterial anomalies of the aortic branches Cardiac defects and coarctation of the aorta Eye anomalies Sternal defects and supraumbilical raphev
PHACES syndrome
What are nevus cell nests that are exclusively within the dermis called?
intradermal nevi
A Nevus sebaceus on the scalp is associated with ____.
allopecia
What mutation is assoc. with Port Wine Stains?
GNAQ
What is the tx for Sebaceus hyperplasia?
none- cosmetic issue only
What is Sebaceus hyperplasia?
common benign tumor of the oil gland
____ will stain with GLUT-1.
Infantile hemangiomas
Why do you have to watch a Nevus sebaceus?
up to 30% transform into epithelial neoplasms
Where are Sebaceus hyperplasia found on the skin?
face>trunk>extremities
Nevi are classified depending on ____.
the location of the melanocytic nests
What are compound nevi?
nevus cell nests are present at the dermal epidermal junction and within the dermis
What is Kasabach-Merritt syndrome and what skin finding is it assoc. with?
a consumptive thrombocytopenic coagulopathy associated with large infantile hemangiomas
What is PHACES syndrome?
a disorder characterized by: Posterior fossa malformations Hemangiomas Arterial anomalies of the aortic branches Cardiac defects and coarctation of the aorta Eye anomalies Sternal defects and supraumbilical raphe
Muir-Torre syndrome is assoc. with which skin finding?
Sebaceus hyperplasia
What is a Nevus sebaceus?
a papillomatous, yellow-orange linear plaque on the face or scalp
What are intradermal nevi?
nevus cell nests exclusively within the dermis
What is the Sign of Leser-Trelat?
sudden onset of multiple SKs associated with adenocarcinoma of the stomach
What does a Sebaceus hyperplasia look like?
1-6 mm yellowish-white papule (globules) with central dell
Where are dermatofibromas usually found?
on the legs
