viral oncogenes

Question 1

adenovirus

Answer 1

type 2, 5, 12

no tumor

no cofactros

important experimental model

Question 2

hepadnavirus

Answer 2

hep b

hepatocellular carcinoma

cofactors are aflatoxin, ETOH, smoking

causative

Question 3

herpesvirus

Answer 3

Epstein barr virus

burkitt's lymphoma (cofactor is malaria) EBV
EBV assicated malingnancy in immunosuppressed people (cofactor is immunodeficiency) Causative
nasopharyngeal carcinoma (nitrosamines, genetic cofactors) Causative 
hodgkin lymphoma variable 
gastric carcinoma variable 

KSHV (HSV8)

kaposi sarcoma (cofactor is aids) causative
castleman’s disease causative
primary effusion lymphomas caustiive
primary effusion lymphomas cofactor, causative

Question 4

flavivirus

Answer 4

hep C

hepatocellular carcinoma, aflatotoxin, causative

Question 5

papiloma virus

Answer 5

HPV 16, 18, 31, 33, 35, 39, others

anogenital cancers, upper airway cancers

smoking, oral contraceptives, others

causative

HPV5, 8, 17, 20, 47

skin cancers

genetic disorder, UV, immunosupression

unclear if causitive

Question 6

polyomavirus

Answer 6

MCV, mercel cell cancer, UV, immun supressed, likele causitive

BK, ?prostate preneoplastic lesions, no cofactors, unclear if causitive

JC, ?brain tumors, no cofactros, unclear if causative

SV40, ?mesotheliomas, brain tumors, etc, no cofactors, unclear if causative

Question 7

retroviruses

Answer 7

HTLV1-ATL, ?genetic, causative

HTLV2, no tumor, no cofactors, no malignancy