variations for GPCR signaling

Question 1

Gs-activates adenylate cyclase

Answer 1

signal binds to GPCR 
GTP becomes GDP and 
yB splits from Ga with GTP bound 
Ga-GTP activates adenylyl cyclase wtih ATP to cAMP 
cAMP activates PDE with AMP 

PKa activates to phosphorylate target proteins to after their activity

Question 2

Gi inhibits adenulate cyclase

Answer 2

signal binds to GPCR
GTP to GDP
yB splits from Ga-GTP and
no cAMP is produced so PKA is not activated

Question 3

Gt stimulates cGMP phospodiesterase

Answer 3

light stimulates GPCR 
GTP to GDP 
yB splits from Ga-GTP 
gCMP makes 5'GMP 
cGMP-PDE activated

Question 4

Gq activates phospholipase C

Answer 4

signal binds GPCR
GTP to GDP
yB to GaGTP
activates PLC which makes DAG which makes
PKC which phosphorylation of trget proteins
IP3 makes CA do stuff

Question 5

Epinephrine

Answer 5

goes through Gs with beta adrenergic receptor

non selective agnostic of all adrenergic receptors

major subtypes a1, a2, b1, b2, b3

undergo multiple GPCR signaling pathways

Question 6

histamine

Answer 6

goes through Gs

Question 7

epi/norepi go through

Answer 7

Gi via beta adrenergic receptors

Question 8

dopamine undergoes

Answer 8

Gi via dopamine D2 receptor

Question 9

acetylcholine goes through

Answer 9

Gq via muscarinic acetylchole M3 receptor

Question 10

light goes through

Answer 10

Gt via rhodopsin