Viral Hepatitis (Quiz 3) Flashcards
what is the best test to detect acute hepatitis A
persists for how long
- Anti-HAV IgM
- persists for about 6 months
which indicates prior hepatitis A infection and/or prior vaccination
also protects against reinfection
- Anti-HAV IgG
what indicates acute Hep B infection
- HBsAg
what indicates immunity to hepatitis B due to vaccination
what indicates a marker of infection currently or in the past
- Anti-HBs
- Anti-HBc
what is the sole marker of infection during the window period for Hepatitis B
- Anti-HBc IgM
what part of Hepatitis B virus indicates active viral replication and high transmissibility and poorer prognosis
- HBeAg
what indicates low transmissibility of hepatitis B
- anti-HBe
which hepatitis virus is the only DNA virus
- Hep B
which hepatitis virus results in chronic hepatitis
- Hep B
- Hep C
- Hep D
which hepatitis viruses can cause cirrhosis of the liver
- Hep B
- Hep C
- Hep D
elevated bilirubin in tissues causes what
- jaundice
elevated bilirubin metabolites in urine causes what
- dark urine
acute hepatitis is how long
- less than 6 months
chronic hepatitis is how long
- more than 6 months
chronic hepatitis is scored based on the degree of
- inflammation and fibrosis
genome of hepatitis A virus
+ ssRNA
how does hep A circulate in the blood
- wrapped in host membranes that it steals from hepatocytes
transmission of Hep A virus
- fecal-oral through contaminated food and water
what liver enzyme is elevated with hepatitis A infection
- ALT
resolution and clearance of hepatitis A virus from liver correlates with
- CD4+ specific T cell response
what can be given as post exposure prophylaxis for Hep A
- HAV vaccine
- immunoglobulin
structures of Hep C virus
+ssRNA with envelope
which virus has an extreme genetic heterogeneity
- Hep C
what are important components of Hep C for direct-acting antivirals
how should we dose these direct acting anvirals
- replicase components
- NS3/4A - serine protease
- NS5A - replicase complex formation
- NS5B - RdRp
- always in combinations
acute Hep C infection is often
- asymptomatic
what happens to most people infected with Hep C
- 70% become chronically infected
which virus replicates as quasispecies swarm of closely related, but distinct RNA sequences that undergo continued evolution in the host, with selection driven in part by virus-specific antibodies and T lymphocytes
- Hepatitis C
transmission of Hep C occurs how
- exposure to blood
is it possible to cure HCV infection
- yes
structure of Hep B virus
- partially dsDNA
- outer envelope with inner protein nucleocapsid core
which virus requires HBsAg for completion of its own life cycle
- hepatitis delta virus
transmission of Hep B virus
- from blood
what is the window period in hepatitis B infection
- when HBsAg and Anti-HBs are both negative
