Viral Hepatitis (Quiz 3)

Question 1

what is the best test to detect acute hepatitis A

persists for how long

Answer 1

• Anti-HAV IgM

- persists for about 6 months

Question 2

which indicates prior hepatitis A infection and/or prior vaccination

also protects against reinfection

Answer 2

• Anti-HAV IgG

Question 3

what indicates acute Hep B infection

Answer 3

• HBsAg

Question 4

what indicates immunity to hepatitis B due to vaccination

what indicates a marker of infection currently or in the past

Answer 4

• Anti-HBs

- Anti-HBc

Question 5

what is the sole marker of infection during the window period for Hepatitis B

Answer 5

• Anti-HBc IgM

Question 6

what part of Hepatitis B virus indicates active viral replication and high transmissibility and poorer prognosis

Answer 6

• HBeAg

Question 7

what indicates low transmissibility of hepatitis B

Answer 7

• anti-HBe

Question 8

which hepatitis virus is the only DNA virus

Answer 8

• Hep B

Question 9

which hepatitis virus results in chronic hepatitis

Answer 9

• Hep B
• Hep C
• Hep D

Question 10

which hepatitis viruses can cause cirrhosis of the liver

Answer 10

• Hep B
• Hep C
• Hep D

Question 11

elevated bilirubin in tissues causes what

Answer 11

• jaundice

Question 12

elevated bilirubin metabolites in urine causes what

Answer 12

• dark urine

Question 13

acute hepatitis is how long

Answer 13

• less than 6 months

Question 14

chronic hepatitis is how long

Answer 14

• more than 6 months

Question 15

chronic hepatitis is scored based on the degree of

Answer 15

• inflammation and fibrosis

Question 16

genome of hepatitis A virus

Answer 16

+ ssRNA

Question 17

how does hep A circulate in the blood

Answer 17

• wrapped in host membranes that it steals from hepatocytes

Question 18

transmission of Hep A virus

Answer 18

• fecal-oral through contaminated food and water

Question 19

what liver enzyme is elevated with hepatitis A infection

Answer 19

• ALT

Question 20

resolution and clearance of hepatitis A virus from liver correlates with

Answer 20

• CD4+ specific T cell response

Question 21

what can be given as post exposure prophylaxis for Hep A

Answer 21

• HAV vaccine

- immunoglobulin

Question 22

structures of Hep C virus

Answer 22

+ssRNA with envelope

Question 23

which virus has an extreme genetic heterogeneity

Answer 23

• Hep C

Question 24

what are important components of Hep C for direct-acting antivirals

how should we dose these direct acting anvirals

Answer 24

• replicase components
• NS3/4A - serine protease
• NS5A - replicase complex formation
• NS5B - RdRp
• always in combinations

Question 25

acute Hep C infection is often

Answer 25

- asymptomatic

Question 26

what happens to most people infected with Hep C

Answer 26

- 70% become chronically infected

Question 27

which virus replicates as quasispecies swarm of closely related, but distinct RNA sequences that undergo continued evolution in the host, with selection driven in part by virus-specific antibodies and T lymphocytes

Answer 27

- Hepatitis C

Question 28

transmission of Hep C occurs how

Answer 28

- exposure to blood

Question 29

is it possible to cure HCV infection

Answer 29

- yes

Question 30

structure of Hep B virus

Answer 30

- partially dsDNA | - outer envelope with inner protein nucleocapsid core

Question 31

which virus requires HBsAg for completion of its own life cycle

Answer 31

- hepatitis delta virus

Question 32

transmission of Hep B virus

Answer 32

- from blood

Question 33

what is the window period in hepatitis B infection

Answer 33

- when HBsAg and Anti-HBs are both negative