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GI Final > Viral Hepatitis (Quiz 3) > Flashcards

Viral Hepatitis (Quiz 3) Flashcards

1
Q

what is the best test to detect acute hepatitis A

persists for how long

A
  • Anti-HAV IgM

- persists for about 6 months

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2
Q

which indicates prior hepatitis A infection and/or prior vaccination

also protects against reinfection

A
  • Anti-HAV IgG
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3
Q

what indicates acute Hep B infection

A
  • HBsAg
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4
Q

what indicates immunity to hepatitis B due to vaccination

what indicates a marker of infection currently or in the past

A
  • Anti-HBs

- Anti-HBc

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5
Q

what is the sole marker of infection during the window period for Hepatitis B

A
  • Anti-HBc IgM
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6
Q

what part of Hepatitis B virus indicates active viral replication and high transmissibility and poorer prognosis

A
  • HBeAg
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7
Q

what indicates low transmissibility of hepatitis B

A
  • anti-HBe
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8
Q

which hepatitis virus is the only DNA virus

A
  • Hep B
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9
Q

which hepatitis virus results in chronic hepatitis

A
  • Hep B
  • Hep C
  • Hep D
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10
Q

which hepatitis viruses can cause cirrhosis of the liver

A
  • Hep B
  • Hep C
  • Hep D
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11
Q

elevated bilirubin in tissues causes what

A
  • jaundice
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12
Q

elevated bilirubin metabolites in urine causes what

A
  • dark urine
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13
Q

acute hepatitis is how long

A
  • less than 6 months
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14
Q

chronic hepatitis is how long

A
  • more than 6 months
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15
Q

chronic hepatitis is scored based on the degree of

A
  • inflammation and fibrosis
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16
Q

genome of hepatitis A virus

A

+ ssRNA

17
Q

how does hep A circulate in the blood

A
  • wrapped in host membranes that it steals from hepatocytes
18
Q

transmission of Hep A virus

A
  • fecal-oral through contaminated food and water
19
Q

what liver enzyme is elevated with hepatitis A infection

A
  • ALT
20
Q

resolution and clearance of hepatitis A virus from liver correlates with

A
  • CD4+ specific T cell response
21
Q

what can be given as post exposure prophylaxis for Hep A

A
  • HAV vaccine

- immunoglobulin

22
Q

structures of Hep C virus

A

+ssRNA with envelope

23
Q

which virus has an extreme genetic heterogeneity

A
  • Hep C
24
Q

what are important components of Hep C for direct-acting antivirals

how should we dose these direct acting anvirals

A
  • replicase components
  • NS3/4A - serine protease
  • NS5A - replicase complex formation
  • NS5B - RdRp
  • always in combinations
25
Q

acute Hep C infection is often

A
  • asymptomatic
26
Q

what happens to most people infected with Hep C

A
  • 70% become chronically infected
27
Q

which virus replicates as quasispecies swarm of closely related, but distinct RNA sequences that undergo continued evolution in the host, with selection driven in part by virus-specific antibodies and T lymphocytes

A
  • Hepatitis C
28
Q

transmission of Hep C occurs how

A
  • exposure to blood
29
Q

is it possible to cure HCV infection

A
  • yes
30
Q

structure of Hep B virus

A
  • partially dsDNA

- outer envelope with inner protein nucleocapsid core

31
Q

which virus requires HBsAg for completion of its own life cycle

A
  • hepatitis delta virus
32
Q

transmission of Hep B virus

A
  • from blood
33
Q

what is the window period in hepatitis B infection

A
  • when HBsAg and Anti-HBs are both negative

GI Final (27 decks)

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