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GI Final > Inflammatory Bowel Disease (Quiz 2) > Flashcards

Inflammatory Bowel Disease (Quiz 2) Flashcards

1
Q

what two diseases does IBD include

A
  • ulcerative colitis

- Chron’s disease

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2
Q

cryptitis, crypt abscess and ulceration are indicative of what condition

A
  • active colitis
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3
Q

what is present in active colitis

A
  • neutrophils
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4
Q

what is it called when neutrophils are present within crypt epithelium

A
  • cryptitis
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5
Q

what is it called when neutrophils are within the crypt lumen

A
  • crypt abscess
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6
Q

what is it called when there is inflammatory disruption of mucosal surface

A
  • ulceration
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7
Q

what is altered crypt architecture and increased lamina propria chronic inflammation indicative of

A
  • chronic colitis
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8
Q

what encompasses altered crypt architecture

A
  • crypt disarray - not uniform in size and distribution
  • crypt dropout - loss of crypts (atrophy)
  • crypt branching
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9
Q

what is chronic colitis with superimposed active colitis

A
  • chronic active colitis
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10
Q

what is it called when there is an increased number of plasma cells between crypt bases and muscularis mucosae

A
  • basal plasmacytosis
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11
Q

what is IBD characterized by

A
  • chronic recurrent inflammation in GI tract
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12
Q

racial and ethnic populations more likely to get IBD

A
  • white and Jewish
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13
Q

smoking effect on ulcerative colitis

smoking effect on Chrons

A
  • decreased disease activity

- increased disease activity

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14
Q

appendectomy effect on ulcerative colitis

appendectomy effect on Chrons

A
  • protective

- no role`

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15
Q

potential causes of IBD

A
  • genetic susceptibility
  • immune dysregulation
  • environmental factors
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16
Q

ulcerative colitis is an inflammatory disease where

A
  • limited to the colon
17
Q

inflammation in ulcerative colitis is

A
  • continuous
18
Q

ulcerative colitis always involves the

A
  • rectum
19
Q

ulcerative colitis inflammation mainly involves which layer

A
  • mucosa

- superficial ulceration and exudate

20
Q

big symptoms of ulcerative colitis

A
  • intense diarrhea (bloody)
  • urgency
  • tenesmus
21
Q

which ulcerative colitis is of the rectum only

A
  • proctitis
22
Q

which ulcerative colitis is up to the splenic fixture

A
  • left sided colitis
23
Q

which ulcerative colitis is beyond the splenic fixture

A
  • extensive/pancolitis
24
Q

important complications of ulcerative colitis

A
  • toxic megacolon leading to perforation and sepsis

- colon cancer

25
Q

gross features of ulcerative colitis

A
  • hemorrhagic granular mucosa

- pseudopolyps

26
Q

what are the histologic features of ulcerative colitis

A
  • lymphoplasmacytic infiltrate that expands lamina proper
  • crypt abnormalities of chronic inflammation
  • inflammation limited to mucosa
27
Q

Chron disease is present in what part of the GI tract

most common place

A
  • any part of the GI tract

- terminal ileum

28
Q

inflammation in Chron disease can be characterized as

A
  • discontinuous/patchy
29
Q

gross features of lesions in Chron disease

A
  • segmental appearance
  • skip lesions
  • Cobblestoning
  • fat wrapping
30
Q

inflammation in Chron disease affects what portion of the bowel wall

A
  • full thickness of bowel wall
31
Q

symptoms of Chron disease

A
  • diarrhea
  • abdominal pain
  • growth retardation in children
32
Q

complications of Chron disease

A
  • inflammation
  • stricture/obstruction
  • fistulization
33
Q

best diagnostic tool for ulcerative colitis and Chron’s disease

A
  • Colonoscopy
34
Q

important findings in histology of Chron disease

A
  • granulomas within mucosa or deeper in bowel wall
35
Q

extra-intestinal manifestations of IBD

A
  • skin
  • joints
  • eyes
  • mouth ulcerations
36
Q

skin manifestations of IBD

A
  • erythema nodosum
  • cutaneous Chron disease
  • pyoderma gangrenosum

GI Final (27 decks)

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