Inflammatory Bowel Disease (Quiz 2) Flashcards
what two diseases does IBD include
- ulcerative colitis
- Chron’s disease
cryptitis, crypt abscess and ulceration are indicative of what condition
- active colitis
what is present in active colitis
- neutrophils
what is it called when neutrophils are present within crypt epithelium
- cryptitis
what is it called when neutrophils are within the crypt lumen
- crypt abscess
what is it called when there is inflammatory disruption of mucosal surface
- ulceration
what is altered crypt architecture and increased lamina propria chronic inflammation indicative of
- chronic colitis
what encompasses altered crypt architecture
- crypt disarray - not uniform in size and distribution
- crypt dropout - loss of crypts (atrophy)
- crypt branching
what is chronic colitis with superimposed active colitis
- chronic active colitis
what is it called when there is an increased number of plasma cells between crypt bases and muscularis mucosae
- basal plasmacytosis
what is IBD characterized by
- chronic recurrent inflammation in GI tract
racial and ethnic populations more likely to get IBD
- white and Jewish
smoking effect on ulcerative colitis
smoking effect on Chrons
- decreased disease activity
- increased disease activity
appendectomy effect on ulcerative colitis
appendectomy effect on Chrons
- protective
- no role`
potential causes of IBD
- genetic susceptibility
- immune dysregulation
- environmental factors
ulcerative colitis is an inflammatory disease where
- limited to the colon
inflammation in ulcerative colitis is
- continuous
ulcerative colitis always involves the
- rectum
ulcerative colitis inflammation mainly involves which layer
- mucosa
- superficial ulceration and exudate
big symptoms of ulcerative colitis
- intense diarrhea (bloody)
- urgency
- tenesmus
which ulcerative colitis is of the rectum only
- proctitis
which ulcerative colitis is up to the splenic fixture
- left sided colitis
which ulcerative colitis is beyond the splenic fixture
- extensive/pancolitis
important complications of ulcerative colitis
- toxic megacolon leading to perforation and sepsis
- colon cancer
gross features of ulcerative colitis
- hemorrhagic granular mucosa
- pseudopolyps
what are the histologic features of ulcerative colitis
- lymphoplasmacytic infiltrate that expands lamina proper
- crypt abnormalities of chronic inflammation
- inflammation limited to mucosa
Chron disease is present in what part of the GI tract
most common place
- any part of the GI tract
- terminal ileum
inflammation in Chron disease can be characterized as
- discontinuous/patchy
gross features of lesions in Chron disease
- segmental appearance
- skip lesions
- Cobblestoning
- fat wrapping
inflammation in Chron disease affects what portion of the bowel wall
- full thickness of bowel wall
symptoms of Chron disease
- diarrhea
- abdominal pain
- growth retardation in children
complications of Chron disease
- inflammation
- stricture/obstruction
- fistulization
best diagnostic tool for ulcerative colitis and Chron’s disease
- Colonoscopy
important findings in histology of Chron disease
- granulomas within mucosa or deeper in bowel wall
extra-intestinal manifestations of IBD
- skin
- joints
- eyes
- mouth ulcerations
skin manifestations of IBD
- erythema nodosum
- cutaneous Chron disease
- pyoderma gangrenosum
