Toxic and Metabolic Liver Disease (Quiz 3) Flashcards
what causes fatty liver diseases
- accumulation of triglycerides in the hepatocyte cytoplasm
risk factors for fatty liver disease
- metabolic syndrome
- excessive alcohol consumption
what is needed in addition to steatosis to establish the diagnosis of steatohepatitis
- lobular inflammation (inflammatory cells)
- hepatocyte ballooning
- hepatocyte death
- fibrosis
what is steatosis
what happens to the nucleus
- deposition of fat in hepatocyte cytoplasm
- nucleus pushed toward periphery
steatosis begins in which zone first
- centrilobular zone
will fibrosis reverse following reduction in risk factors
- no
what do we call a ballooned hepatocyte that is larger with a pale swollen cytoplasm and a cytoplasm containing clumped cytoskeletal filaments
what’s the hyaline cytoskeleton called
what condition are they usually indicative of
- Mallory-Denk bodies
- Mallory’s hyaline
- alcoholic steatohepatitis
the end stage of steatohepatitis is
- cirrhosis
as cirrhosis evolves _______ often becomes less apparent
- steatosis
without consumption of alcohol
what is the presence of >5% hepatic steatosis without evidence of hepatocellular injury
non-alcoholic fatty liver
without consumption of alcohol
what is the presence of >5% hepatic steatosis WITH evidence of inflammation/hepatocyte injury
non-alcoholic steatohepatitis
which ethnicity is at greatest risk for NAFLD
which gender
- hispanics
- men
what conditions can lead to metabolic syndrome
- elevated triglycerides
- low HDL
- insulin resistance
- obesity
- HTN
how does adipose tissue cause fatty liver disease
- releases proinflammatory factors (TNF-alpha, IL-6)
alcoholics absorb more _____ from the gut
then what happens
- endotoxin
- endotoxin activates Kupffer cells which secrete TNF-alpha and cause hepatocyte death
