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GI Final > IBD Pharm (Quiz 4) > Flashcards

IBD Pharm (Quiz 4) Flashcards

1
Q

Aminosalicytes are used for what severity and condition

A
  • mild ulcerative colitis
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2
Q

thiopurines are used for what severity

A
  • moderate disease
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3
Q

biologics are used for what severity

A
  • severe disease
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4
Q

we use steroids for what kind of therapy

duration and dose?

A
  • short term bridge therapy

- short duration and lowest dose

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5
Q

we use surgery for what in IBD

A
  • medically refractory disease
  • complications
  • cancer/dysplasia of bowel
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6
Q

what is induction therapy

A
  • treating the flare
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7
Q

what is maintenance therapy

A
  • long term treatment
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8
Q

do we use corticosteroids for induction or maintenance

do we use it for Chrons or ulcerative colitis

A
  • induction only

- both

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9
Q

for corticosteroids need to _______ to prevent renal insufficiency

A
  • taper off
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10
Q

MOA for corticosteroids

A
  • enter cell nucleus and influence DNA gene expression
  • anti-inflammatory effects
  • immune suppression
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11
Q

how do you take prednisone

A
  • orally
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12
Q

Budesonide is what kind of medication

A
  • steroid
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13
Q

Budesonide enteric capsules have _______ release

A
  • ileal
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14
Q

Budesonide multimatrix has _______ release

A
  • colonic
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15
Q

importance of Budesonide with enterohepatic circulation

A
  • has rapid first pass metabolism

- less systemic effects

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16
Q

side effects of corticosteroids

A
  • osteoporosis
  • immune suppression/infection
  • weight gain
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17
Q

do we use aminosalicytes for induction or maintenance therapy

for what condition

A
  • both

- ulcerative colitis

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18
Q

medications that are aminosalicylates

A
  • 5-aminosalicylic acid
  • sulfasalazine
  • balsalazine
  • olsalazine
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19
Q

MOA of aminosalicylates

A
  • topical anti-inflammatory agent in GI tract
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20
Q

rare side effects of aminosalicylates

A
  • pancreatitis

- interstitial nephritis

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21
Q

we use oral delayed release capsules of aminosalicylates for what location

A
  • entire colon
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22
Q

we use rectal enema of aminosalicylates for what location

A
  • up through sigmoid colon
23
Q

we use rectal foam of aminosalicylates for what location

A
  • entire rectum
24
Q

we use rectal suppository of aminosalicylates for what location

A
  • anus
25
Q

what drugs are the thiopurines

A
  • azathioprine
  • 6-mercaptopurine
  • methotrexate
26
Q

speed of azathioprine,6-MP

A
  • slow
27
Q

do we use azathioprine,6-MP for induction or maintenance?

A
  • maintenance
28
Q

if we need to use azathioprine,6-MP for induction, what do we need to do first

A
  • steroid bridge
29
Q

MOA of azathioprine,6-MP

A
  • inhibits nucleotide synthesis

- prevent proliferation of B and T lymphocytes

30
Q

measure ______ levels to guide dosing/therapy of azathioprine,6-MP

A
  • 6-TGN
31
Q

side effects of azathioprine,6-MP

A
  • bone marrow suppression

- cancer risk

32
Q

what kind of cancer can azathioprine,6-MP cause

A
  • lymphoma

- nonmelanoma skin cancer

33
Q

methotrexate MOA

A
  • interferes with purine DNA synthesis
34
Q

big side effect of methotrexate

A
  • teratogenic in pregnancy
35
Q

how do we administer monoclonal antibodies

A
  • IV infusion

- subcutaneous injection

36
Q

problem with monoclonal antibodies and patient immune system

A
  • immune system can make Ab against drug and neutralize it
37
Q

Anti-TNF monoclonal antibodies

A
  • infliximab
  • adalimumab
  • certolizumab
  • golimumab
38
Q

gold standard therapy for moderate to severe IBD

A
  • anti-TNF meds
39
Q

which Anti-TNF alpha med is used for UC only

A
  • Adamlimumab
40
Q

which anti-TNF alpha med is used for Chrons only

A
  • certolizumab pegol
41
Q

MOA of anti-TNF biologics

A
  • inhibits T cell activation
42
Q

do we use anti-TNF meds for induction or maintenance

A
  • both
43
Q

risks of anti-TNF meds

A
  • infection
  • lymphoma/melanoma
  • exacerbation of heart failure
44
Q

what is the first gut targeted medication for IBD

A
  • vedolizumab
45
Q

MOA of vedolizumab

A
  • gut selective integrin inhibitor

- white cell can’t migrate into gut tissue

46
Q

do we use vedolizumab for induction or maintenance therapy

A
  • both
47
Q

vedolizumab risks

A
  • very little immunosuppression risk
48
Q

Ustekinumab used for UC or Crohns

induction or maintenance

A
  • Crohns only

- both

49
Q

MOA of Ustekinumab

A
  • inhibits p40 of IL12 and IL23

- inhibits downstream JAK/STAT

50
Q

Ustekinumab risks

A
  • systemic immune suppression/infection
51
Q

Tofacinitib used for UC/Crohns

induction or maintenance

A
  • UC only

- both

52
Q

is Tofacinitib an antibody

MOA

A
  • no

- inhibits JAK/STAT signaling pathway

53
Q

in what form do we give Tofacinitib

A
  • tablet
54
Q

risks of Tofacinitib

A
  • systemic immune suppression/infection

- elevated cholesterol and LFTs

GI Final (27 decks)

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