VIral hepatitis Flashcards
markers of hepatocyte inflammation? of biliary tree inflammation?
ALT and AST elevation. Alk Phos and GGT elevation
Which (A-E) viruses are chronic? what type of genetic material? Pattern of transmission?
BCD can be chronic (esp C). All except B (dsDNA) are ssRNA. BCD are blood/sexual/parenteral which AE are fecal oral
E’s of HEV
enteric, expectant mothers, epidemic (waterborne)
what type of virus are Hep A-E
Picorna, hepadna, flavi, delta, hepe
incubation period for Hep A-E
A-short, B-long, C-long, D-short superinfect and long co-infect, E-short
ground glass appearing hepatocytes
Hep B surface Ag in cytoplasm
cut off for acute/chronic HBV infection
6 months
Significance of Anti-HAV IgM and IgG serum markers
IgM- best test for active hepA. IgG- prior HAV infection and/or vaccination
Significance of HBsAg, Anti-HBs
indicates HepB infection.
Indicates immunity to hepB (recovered (will have Anti-HBc) or immunized)
Anti-HBc: IgM and IgG.
IgM- acute/recent infection.
IgG- prior exposure or chronic infection. Positive during window period
Window period
month in between when HBsAg become indetectable and Anti-HBs become detecatable. Anti-HBc positive during this time.
HBeAg and Anti-HBe
second antigenic determinant in HBV core. Indicates active viral replication (high transmissibility)
Indicates low transmissibility
ALT>AST, AST>ALT
viral hepatitis, alcoholic hepatitis
Markers of HBV infection in the order they appear
SECES: SE antigens, CES antibodies
which hepatitis virus is most commonly sexually transmitted? how would it present? which is most commonly associated with blood transfusion
HBV, jaundice
HCV
which most commonly lead to HCC
B and C
Hep B vaccine is made of___
HBsAg
features of acute viral hepatitis histology
lobule necrosis and regeneration, bridging necrosis, massive necrosis
features of HCV chronic hepatitis
mononuclear reaction, lymphoid aggregates, steatosis, cirrhosis, HCC
