126/127B Nutrition Flashcards

1
Q

What are DRI’s/RDA’s?

A

Dietary reference intakes, recommended daily allowances. A set of standards for vitamin intake for normal, healthy patients that don’t have frank deficiencies to help prevent disease.

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2
Q

What is the 6 food elimination diet used to treat? What does it remove from the diet?

A

EOE. Removes the top 6 allergens. Wheat, dairy, soy, nuts, eggs, fish/shellfish (creates some nutritional deficiencies)

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3
Q

What does wheat provide in the diet?

A

Vitamin B, calories (makes up 60-70% of total)

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4
Q

What is milk the major source of in the diet?

A

Calcium and vitamin D

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5
Q

Do you get water-soluble or fat-soluble vitamin deficiencies faster?

A

Water soluble

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6
Q

Lecture question: if someone goes on the 6 food elimination diet, what do you need to replace to avoid deficiencies?

A

Calories, calcium, vitamin D, folic acid, magnesium

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7
Q

What is celiac disease?

A

An autoimmune enteropathy (Ab against gluten), related to DQ2/DQ8 HLA haplotype

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8
Q

What is damaged in celiac disease?

A

Villi atrophy in small intestine from autoantibodies. Leads to nutrient deficiencies from disruption of the enzymes at the brush border.

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9
Q

How do you treat celiac disease?

A

Lifelong gluten-free diet

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10
Q

Inability to maintain normal levels of what nutrient suggests an absorption disorder?

A

Iron

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11
Q

What micronutrients are you concerned about with celiac disease?

A

B vitamins (folate/B-12, thiamin, riboflavin), fat soluble vitamins (KADE), iron

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12
Q

Nutritional complication of celiac disease?

A

Ostopenia/osteoporosis (vitamin D deficiency)

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13
Q

Lecture question: which blood tests do you want to get if you are suspicious of celiac disease?

A

Iron, vitamin D, B12, and folic acid

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14
Q

Why do people with IBD cholitis get deficiencies?

A

1) Flare-ups damage the small intestine directly and 2) they restrict their diet because of GI symptoms

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15
Q

What foods should be limited during a IBD flare?

A

Lactose, fat, carbohydrates, fiber

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16
Q

Lecture question: due to fecal fat loss for a patient with an IBD flare, what nutrients are you most concerned about?

A

B12 + fat soluble vitamins (KADE)

17
Q

What are the two types of IBD?

A

Crohn’s and ulcerative cholitis

18
Q

Why do people with EOE get nutrient deficiencies?

A

Because of the treatment (6-food elimination diet), not because of malabsorption

19
Q

What are the three ways Vit. D increases serum Ca?

A

1) raises PTH levels (which releases Ca from bone), 2) absorb more in gut, 3) resorb more in nephrons

20
Q

What do you have to supplement kids that are breastfed with?

A

Vitamin D - poorly disseminated in breast milk

21
Q

What is Trousseau’s sign and what does it indicate?

A

Tetany of the arm on BP cuff inflation, severe vitamin D deficiency

22
Q

What are some good food sources of Vit. D?

A

Fish, fortified milk/orange juice, supplements

23
Q

What are two functional roles of Vit. A?

A

Night vision (rhodopsin precursor), immunity (deficiency predisposes to pneumonia)

24
Q

What are Bitot spots and what do they indicate?

A

Clumps of keratinized cells in the eyes, vitamin K deficiency

25
Q

What are the two forms of Vit. A?

A

Retinal (animal products) and carotenoid (plant products)

26
Q

What are the three forms of thiamine deficiency?

A

Wet (cardiac) beriberi, dry (neuropathy) beriberi, Wernicke-Korsakoff (cerebral beriberi)

27
Q

What do you get in wet beriberi?

A

High output HF, cardiomegaly, pitting edema, neuropathy

28
Q

What do you get in dry beriberi?

A

Peripheral neuropathy, foot/wrist drop, lost of reflexes/sensation, weakness

29
Q

What do you get in Wernicke-Korsakoff?

A

Ataxia, confusion, impaired memory, confabulation

30
Q

What clinical signs do you see with riboflavin (B2) deficiency?

A

Oral symptoms. Magenta tongue, cheilosis (cracks), angular stomatitis (sores)

31
Q

What clinical signs do you see with pellagra/niacin (B3) deficiency?

A

“3 D’s” triad: dermatitis (Casal’s necklace), diarrhea, dementia. People die a lot.

32
Q

Lecture question: given a shortage of IV multivitamins, what would be the cause of death in patients presenting with acidosis?

A

B-vitamin deficiency, particularly thiamine/B12. Get a buildup of pyruvate, don’t make enough energy.

33
Q

What can folic acid deficiency cause?

A

Neural tube defects in babies, megaloblastic anemia in adults

34
Q

What drugs do you need to supplement patients with folic acid for?

A

Methotrexate, valproic acid, chronic PPI therapy

35
Q

What type of diet gets no B12?

A

Vegan

36
Q

What is a clinical manifestation of iodine deficiency?

A

Goiter

37
Q

What deficiencies do GI surgery patients get?

A

Zinc, iodine, iron

38
Q

Lecture question: woman that had gastric bypass surgery has a desire to eat non-food items (pica), especially ice. What deficiency is responsible?

A

Iron deficiency anemia

Also seen in pregnancy