Histology of esophageal disorders Flashcards

1
Q

what percent of total epithelial thickness should the basal layer occupy?

A

less than 15%

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2
Q

endoscopic and histologic findings in reflux esophagitis

A

hyperemia, patches resembling leukoplakia; basal hyperplasia, extension of papillae to the surface, PMN and Eo infiltration

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3
Q

diagnosis of eosinophilic esophagitis. Etiology?

A

15 or more Eo in 2 or more high power fields or 25 in any HPF. Also microabcesses and dysphagia. Allergic in kids, unknown in adults

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4
Q

path findings in Barrett’s. Pathogenesis?

A

squamous replaced by metaplastic intestinal columnar with goblet cells. GER leads to ulcer, ulcer is re-epithelialized by stem cells in abnormal milieu and become gastric or intestinal type

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5
Q

complications of Barrett’s? classification?

A

adenocarcinoma. low grade dysplasia retains crypts and general structures, high grade dysplasia does not

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6
Q

name benign and malignant epithelial neoplasms

A

Benign: squamous papilloma. Malignant: sq. cell carcinoma, adenocarcinoma, small cell ca.

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7
Q

squamous cell carcinoma incidence by geography and sex

A

highest esophageal cancer throughout world, in US is adenocarcinoma. Men more common in lower third, women in upper third (with plummer-vinson)

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