Clinical hepatitis Flashcards
which of the hepatotropic viruses are cytotoxic?
HCV and HDV-combo of cytotoxicity and immune response. The others cause damage via immune response
Clinical presentation of Hep A? How does this affect who gets vaccinated?
Children are asymptomatic. Immunization not necessary in high endemic areas where most ppl get infected early in life with little morbidity
How does chronic HepB infection relate to age of exposure? Implications for treatment? What do you base perinatal risk on?
perinatal exposure has 90% risk. Mature immune systems (adults) mount vigorous defense, develop clinical hepatitis, then spontaneously clear the virus. (don’t tx symptomatic adults w/ acute hepB). If mother has undetectable DNA then baby is at low risk (no tx necessary)
Three phases of chronic HepB
Immune tolerance: active viral replication (high DNA) but normal liver tests. Do not tx.
Immune reactive/clearance: ‘hepatitis’ from immune response. Ends with seroconversion (replacing HBeAg with Anti-Hbe). Treat.
Inactive carrier: minimal DNA, normal liver tests. (may develop Anti-HBs)
What three things can lack of HBsAg mean? How can you tell if there’s been exposure?
never exposed, cleared infection, or in window period. Anti-HBc tells us there’s been exposure
tx for HepB
oral antivirals (tenofaovir, entecavir) inhibit viral replication (no immune engagement). Interferon stimulates host immune system.
virology of HCV
+RNA translated to peptide. Peptide used to form NS3/NS4A protease. Protease cleaves protein to form polymerase.
treatment for HCV
PEG-interfereon + Ribavirin + telaprevir or boceprevir (anti-protease, targets NS3/NS4A). Future drugs will target polymerase (sofosbuvir) and NS5A
what part of HepB does HBV need and what does that mean?
HBsAg, not DNA. Doesn’t need active HBV