Viral Facts Flashcards
What general principle causes influenza pandemics?
Reassortment - genetic shift
Phenotypic mixing
Two viruses infecting one cell - Virus A takes coat B and can infect new cells - not genetically coded for
What are the DNA viruses?
HHAPPPPy
Hepadna, Herpes, Adeno, Pox, Parvo, Papilloma, Polyoma
Which of the DNA viruses is single stranded?
Parvovirus
Which of the DNA viruses is icosahedral?
All but Pox - complex
Which of the DNA viruses replicates in the nucleus?
All but Pox - brings its own DNA-dep RNA Pol
Which DNA viruses are linear?
All but
Papilloma & Polyoma - circular, supercoiled
Hepadna - circular incomplete, has RT
What are the RNA viruses
I went to a retro toga party, where I drank flavored Corona and ate hippy California pickles Retro Toga Flavi Corona Hepe Calici Picorna
Which of the RNA viruses is single stranded?
All but reovirus
Where does herpesvirus get its envelope from?
Nuclear membrane
What are the naked viruses
PAPP: Papilloma, Adeno, Parvo, Polyoma
CPRH: Calici, Picorna, Reo, Hepe
Hepadnavirus
HBV - has a RT
Sore throat, pneumonia, conjunctivits, acute hemorrhagic cystitis in campers/military recruits
Adenovirus
Parvovirus
B19 - aplastic crisis - fifth disease - slapped cheek rash
Fetus - hydrops fetalis and death
JC virus (Polyoma)
Progressive multifocal leukoencephalopathy - HIV
BK virus (Polyoma)
Kidney - transplant patients
Temporal lobe encephalitis
HSV-1
What 3 disease is EBV associated with?
Hodgkin lymphoma
African/Endemic Burkitt lymphoma
Nasopharyngeal CA
Transplant Pneumonia
AIDs Retinitis
CMV!!
Latent in mononuclear cells
High fevers that can cause seizures followed by diffuse macular rash
HHV-6 (Roseola)
Owl eye inclusions
CMV
Tsank test to detect multi-nucleated giant cells indicates what?
HSV + intranuclear Cowdry A inclusions
1 cause of fatal diarrhea in children
Rotavirus - Reovirus
Polio, Echovirus, Rhinovirus, Coxsackie, HAV
Picornaviruses - aseptic meningitis
Norovirus
Calicivirus - viral gastroenteritis
HCV, yellow fever, dengue, St. Louis encephalitis, West Nile
Flavivirus
Rubella
Togavirus
Retroviruses
HIV and HTLV (T-cell leukemia)
Coronavirus
Common cold
SARS
Orthomyxovirus
-segmented ssRNA
Influenza
Paramyxovirus
-non segmented ssRNA
Croup - parainfluenza
RSV - bronchiolitis
Measles, Mumps
Aedes mosquito
Yellow fever: high fever, black vomitus, and jaundice
Monkey/human reservoir
Flavivirus
Rotavirus
Reovirus - dsRNA
Winter, daycare, kindergartens
Villous destruction w/ atrophy - decreased absorption of Na and loss of K
A humoral reponse with antibodies against ___________ of influenza virus is considered protective.
Hemagglutinin (entry)
All paramyxoviruses contain _________, and causes respiratory epithelial cells to fuse and form ____________________.
F-protein
Multi-nucleated cells
What prevents pneumonia caused by RSV in premature infants?
Palivizumab (anti-F protein)
What are the sequelae of Measles (rubeola)?
Subacute sclerosing panencephalitis - cerebellar/optic probs
Encephalitis
Giant cell pneumonia
What do you give malnourished children with measles to prevent severe exfoliative dermatitis?
Vitamin A
Parotitis, orchitis, and aseptic meningitis
Mumps
Bullet shaped virus with Negri bodies in Purkinje cells of cerebellum and in hippocampal neurons.
Rabies virus - travels to CNS via retrograde transit up axons
How do you treat rabies
Wound cleansing, vaccination and rabies immune globulin
Which of the hepatitis viruses is a DNA virus?
HBV
Which hepatitis virus has a high mortality in pregnant women?
HEV - waterborne epidemics - fulminant hepatitis
HIV gag
p24 capsid
HIV pol - mt results in what?
TR, aspartate protease, integrase
Drug resistance
HIV env mt?
Escape from host antibodies
Esophagitis in AIDS
Candida - patches of grey/white pseudomembranes
HSV1 - punched out ulcers
CMV - linear ucleration
