Viral Diseases of Cats Flashcards

1
Q

What kind of virus is feline panleukopenia virus?

A
  • single stranded DNA virus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Describe the pathogenesis of FPV

A
  • requires rapidly dividing cells
  • initially replicates in oropharynx
  • viremia for 2-7 days
  • lymphoid tissue necrosis, damages cells in intestinal crypts, immunosuppression
  • in utero infections
  • can replicate in neurons
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What are the clinical signs of FPV?

A

peracute: death within 12 hours
- septic shock, dehydration, hypothermia, and coma
acute: most common
- fever, depression, anorexia, vomiting, dehydration, diarrhea, lymphadenopathy, petechiae and ecchymosis

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

How is FPV diagnosed?

A
  • clinical signs and leukopenia
  • serum VN
  • fecal viral antigen: ELISA
  • viral isolation
  • PCR
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

How is FPV treated?

A
  • supportive care
  • fluids and food
  • anti-emetics
  • broad antibiotics
  • IFN
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

What kind of virus is feline coronavirus?

A
  • single stranded RNA virus
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

When does FIP result from coronavirus infection?

A
  • immune mediated vasculitis

- coronavirus within monocytes adhere to blood vessel walls and eztravasate

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Describe the pathogenesis of feline coronavirus

A
  • virus shed in feces
  • replicates in small intestine
  • maintained in environment by chronic shedders
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What type of immune response results in wet FIP?

Which results in dry FIP?

A

wet: absent cell-mediated and strong humoral
dry: intermediated cell-mediated

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

What are the initial clinical signs of feline coronavirus?

A
  • diarrhea, upper resp signs

- multi-systemic inflammatory vasculitis: can be effusive or non-effusive

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the clinical signs of effusive FIP?

A
  • abdominal distension/ascites
  • weight loss, dyspnea, tachypnea
  • pale mucus membranes or icterus
  • muffled heart sounds
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the clinical signs of dry FIP?

A
  • weight loss, dullness, depressed appetite
  • icterus
  • intraocular lesions
  • dyspnea/tachypnea
  • non-suppurative granulomatous meningitis
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

How is feline coronavirus diagnosed?

A
  • gold standard: histopathology (vasculitis)
  • effusion analysis: high protein, Rivalta test
  • CBC: lymphopenia, anemia
  • biochem, CSF, antibody titer
  • alpha-1 acid glycoprotein
  • RT-PCR
  • antigen detection in tissues
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

What kind of virus is feline leukemia virus?

A
  • retrovirus

- single stranded RNA virus with envelop

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

How is feline leukemia virus spread?

A
  • close contact with virus shedding cats
  • through saliva and blood
  • fleas, fomites, etc.
  • transplacentally and nursing
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

What is an abortive infection of feline leukemia virus?

A

the cat never gets the virus due to high levels of neutralizing antibodies in circulation

17
Q

What is a regressive infection of feline leukemia virus?

A
  • cat has an effective immune response
  • virus clear in 3-6 weeks
  • virus is incorporated into their genome
  • reactivation during pregnancy
18
Q

What is a progressive infection of feline leukemia virus?

A
  • extensive replication of virus
  • cats persistently viremic
  • often die within 3 years
19
Q

What are the clinical signs of feline leukemia virus?

A
  • hematopoietic malignancy
  • myelosuppression
  • various co-infections
  • anemia, lymphoma, leukopenia, leukemia
  • fading kitten syndrome
  • neuropathy
20
Q

How is feline leukemia virus diagnosed?

A
  • direct detection of virus: look for p27 antigen (ELISA, direct FA)
  • nucleic acid detection
  • antibody detection
21
Q

How is feline leukemia virus treated?

A
  • hematological: EPO, transfusions, G-CSF
  • antiviral chemotherapy
  • immunomodulatory therapy
  • tumors: chemotherapy
22
Q

What kind of virus is feline immunodeficiency virus?

A
  • lentivirus

- RNA

23
Q

How is FIV transmitted?

A
  • through saliva or blood (bites/wounds)
  • virus found in milk
  • in utero rare
24
Q

Describe the pathogenesis of FIV

A
  • virus initially cleared by macrophages
  • spreads to lymphocytes and macrophages in bone marrow, lungs, intestines, brain, and kidney
  • antibody response mounted, virus levels decrease
  • affects both CD4 and CD8 cells
25
Q

What are the clinical signs of FIV?

A
  • fever, malaise, lymphadenopathy, enteritis, resp disease, stomatitis, dermatitis
  • terminal phase: secondary infection, neurological change, ocular disease, neoplasia
26
Q

How is FIV diagnosed?

A
  • antibody testing
  • viral isolation
  • ELISA, PCR
27
Q

How is FIV treated?

A
  • antiviral chemotherapy (AZT)

- immunomodulatory therapy