Veterinary Medicine - Respiratory Tract Diseases Flashcards
What region: Stertor, Stridor, Reverse sneeze, Cough
Stertor - Nasal cavity, Nasopharynx
Stridor - Larynx, Nasopharynx
Cough - Trachea and Distally
Reverse sneeze - Nasopharynx.
Epistaxis - Diagnostic work up
Blood pressure (Hypertension)
CBC (Thrombocytopenia, PCV/TS)
Biochemistry (e.g. Hyperviscosity syndre causes - Hyperglobulinemia, Hypertriglyceridemia)
PT/PTT (Hypocoagulation)
BMBT (Thrombocytopathy)
Rule out Oro-nasal fistula (Though usually a more mucopurulent secretion)
Imaging (CT) + Rhinoscopy
Cytology
+/- Histopathology
+/- samples for bacteriology +/- mycology.
Epistaxis - Treatment
Lower Blood Pressure: ACP + Benzodiazepines/Opiates
Control Bleeding: Gauze + Adrenaline, Ice Packs
**Ligation of external carotid
**Promote Coagulation: Tranexamic Acid, Yunan Baiyao
**Blood Products
Canine nasal tumor - What tumors are most frequent
Two thirds - Carcinomas
One third - Sarcomas
Round cell - The rest
Canine nasal tumors - Diagnostic work up
CT > MRI
Histology:
CT - Guided
Rhinoscopy Guided
Nasal Hydropulsion
Blind
Cytology - Less Useful. Only for round cell tumors.
What percent of canine nasal tumor histology turn out positive (as opposed to false negative)
70%
Always repeat samples when in doubt
Canine nasal tumors - MST?
3 Months
Canine nasal tumors - Describe radiotherapy (Treatment of choice)
1) Curative-intent high energy megavoltage radiotherapy: 3-5 Visits a week - but less powerful Best MST - 8-20 Months
2) Hypofrctionated palliative radiotherapy Weekly/Bi-weekly visits - but more powerful. MST - 150-500 Days
Canine nasal tumors - Side effects of Curative Intent Radiotherapy?
Acute side-effects: Rhinitis, Keratoconjunctivitis, Oral mucositis, Desquamation of skin
Canine nasal tumors - Side effects of Hypofractionated Palliative RT?
Late side effects: KCS, Cataracts, Retinal or optic disc degeneration, Brain necrosis, Osteonecrosis
Feline nasal tumors - Most frequent kind? MST? Best treatment(s)?
Lymphoma
MST-1000 Days (Great)
Chemotherapy/RT/ Both - All with good prognosis
Nasal polyps in dogs - Signalment? Epithelium-layer origin? How to diagnose? Difference from tumor? Treatment?
Old Dogs
Nasal mucosa
Same as with neoplasia (CT/Biopsy/Rhinoscopy)
Non-invasive
Surgery - Curative
*If there is recurrence - Steroids
Nasal (Not nasopharyngeal) polyps in cats - Signalment? Clinical sign unique to feline nasal polyps as opposed to canine ones? treatment?
Young cats - <1 Year
Epistaxis
Rhinoscopy & Removal
Sinonasal aspergillosis in dogs - Infective? Zoonosis?
No
Sinonasal aspergillosis in dogs - Acute/Chronic? Invasive/Non-Invasive?
Chronic
Non invasive
Sinonasal Aspergillosis in dogs - Signalment, Classic History/Clinical signs
Meta/Dolichocephalic > Brachycephalic
Chronic disease - Weeks to years
Mucopurulent discharge - usually unilateral that can progress to bilateral
Epistaxis
Depigmentation of Nasal Planum
Sinonasal Aspergillosis in dogs - Diagnosis
CT - Turbinates/Cribriform destruction
Rhinoscopy - Fungal plaques/Turbinate destruction
Cytology - (Highest sensitivity when sample is taken from plaques)
Histology
Culture - Mainly for identifying specific species. Doesn’t matter for treatment.
Sinonasal Aspergillosis in dogs - Treatment (Local or systemic?/What drugs are used? Single or multiple treatments?)
Local
Clotrimazole or Enilconazole. Multiple treatments for over 50% of cases are necessary (90-95% success rate). Trephinations (If sinuses are also involved). Extensive debridement can help.
(Systemic treatment - 50%-70% Success Rate).
Aspergillosis in Cats - Signalment? Invasive or Non Invasive? most common lab finding?
Brachycephalic breeds
Tends to be more invasive as opposed to dogs
Hyperglobulinemia
Aspergillosis in Cats - what are the 2 syndromes and which is more invasive? Clinical Signs?
Sino-nasal Aspergillosis:
Stertor
Sneezing
Reverse sneezing
Mucopurulent discharge
Epistaxis
Sino-orbital Aspergillosis (Invasive):
Exophthalmos
3rd Eyelid prolapse
Severe cases - Destruction of hard palate and nasal bones, Fever, Lymphadenopathy. Can also progress to CNS (e.g. Vestibular signs)
Aspergillosis in cats - Treatment
In invasive cases - Systemic treatment in addition to local (e.g. Clotrimazole/Enilconazole + Keto/Flu/Itraconazole)
Surgery with invasive cases also might be indicated
Enucleation
Cryptococcus - Clinical signs/appearance in dogs and cats? Prognosis?
Cats: Local disease that also infects paranasal tissues - very swollen nose bridge
Common URT signs (e.g. Sneezing, Reverse sneezing, Stertor)
Skin lesions
Can progress to ocular and CNS disease
Prognosis - Good when only URT disease (75% Response to treatment), Guarded in CNS cases
Dogs: Systemic disease common Can Involve URT, CNS (50-80% of cases) and eyes
Prognosis - Guarded (50% response to treatment)
Cryptococcus - Diagnosis
Cytology - Diagnostic in 75-90% of cases
Stains - Giemsa/Gram’s
Latex cryptococcal antigen agglutination test - very specific & sensitive for diagnosis and monitoring! Used on: Serum, Urine & CSF
Cryptococcus - Treatment
Treatment - Amphotericin B + Flucytosine / Ampho B + Azoles
Duration - 2 Months after cessation of clinical signs. Alternatively, treatment can be discontinued when antigen titers normalize.
Viral feline rhinitis - what are the viruses?
Calicivirus & Herpes
Feline Calicivirus - Clinical signs and physical exam findings
Lethargy
Anorexia
Fever
Lymphadenopathy
Rhinitis (Sneezing, Sero/mucopurulent discharge)
Stomatitis
Lingual ulcers (Relatively pathognomonic)
Conjunctivitis
Occasionally GI signs (e.g. vomiting, diarrhea)
Feline Herpesvirus - Clinical signs
Lethargy
Anorexia
Fever
Lymphadenopathy
Rhinitis (Sneezing, Sero/mucopurulent discharge)
Stomatitis
Conjunctivitis, Keratitis, Corneal ulcers, Sequestrum
Feline URT Viruses - Treatment
Suppurative:
IV fluids
Appetite stimulant
Anti-emetics (if indicated)
Antipyretics
Analgesia
Antibiotics for 2nd Infections (e.g. Azithromycin / Doxycycline / Augmentin)
Specific treatments: Lysine (indicated when Herpes is suspected)
Famciclovir (indicated when Herpes is suspected)
Treatment for corneal ulcers (If indicated in cases of herpes)
Long term for Herpes - Provide a stress free environment to prevent recurrence
Canine viral rhinitis - dog. Most common viral agent?
Distemper
Causes for bacterial rhinitis? (Primary & secondary anatomical causes)
Primary:
Bordetella
Mycoplasma
Chlamydia
Secondary:
Oro-nasal fistula
Cleft palate
Ciliary dyskinesia
Diagnosis Of Oro-nasal fistula? Common locations?
Signalment - Older animals
History & Clinical signs:
Chronic URT disease clinical signs (Sneezing, Stertor, Reverse sneezing)
Mucopurulent discharge, Unilateral
Diagnosis:
Probe & Florecin staining
Dental x-rays
Common locations: Canines, PM1 & PM2
Treatment of osteomyelitis secondary to rhinitis
AB treatment for 2-4 weeks (e.g. Augmentin +/- Fluoroquinolone)
Canine Lymphoplasmacytic rhinitis & Feline chronic rhinosinusitis - Classic histological changes
-Lymphoplasmocytic infiltrate +/- Eosinophils +/- Neutrophils
-Mucosa - Hyperplastic and squamous metaplastic changes
-Loss of muco-ciliary apparatus
-Hyperplasia of mucus glands
Canine Lymphoplasmacytic rhinitis & Feline chronic rhinosinusitis - Signalment and prevalence
Young to middle aged dolico & mesocephalic breeds (Dachshunds & Whippets over represented)
20-40% of chronic rhinitis in dogs and cats.
Canine Lymphoplasmacytic rhinitis & Feline chronic rhinosinusitis - 2 Most common rhinoscopy findings
Mucosal hyperemia
Secretions
Canine Lymphoplasmacytic rhinitis & Feline chronic rhinosinusitis - Treatment
2 modalities of therapy:
1) Immunomodulatory antibiotics (Azithromycin/Doxycycline) + NSAIDs + Augmenting for 2nd Infections
2) Steroids - If works - switch to MDI. 2nd Immunosuppressant may be add (e.g. Cyclosporine)
Treatment usually prolonged (2-6 months) and start tapering off
Add Vigorous Flushing
Canine Lympho-Plasmocytic Rhinitis & Feline Chronic Rhinosinusitis - Clinical Signs
Sneezing
Reverse Sneeze
Muco-Purulent Secretions
Stertor. Rarely epistaxis
Bilateral disease common
Neurogenic rhinitis - fancy name?
Xeromycteria
Neurogenic rhinitis - Cause
Loss of parasympathetic innervation - Commonly because of otitis media
Neurogenic rhinitis - Common ocular clinical signs / pathologies associated with the disease
KCS
Conjunctivitis
Neurogenic rhinitis - Treatment
Treat underlying cause (e.g. Otitis media)
Artificial eye drops
Nasopharyngeal polyps in cats - Signalment, Specific location, Treatment
Young cats
Eustachian tube => from there extends to the nasopharynx / ear
Surgery + Steroids (To prevent recurrence)
Nasopharyngeal diseases - Common clinical signs
Stertor
Stridor (Cats)
Reverse sneezing
Vomiting
Regurgitation (Negative pressure in thorax)
Nasopharyngeal diseases - Foreign bodies - How do they end up in the nasopharynx
Vomiting / Regurgitation
Nasopharyngeal stenosis - Causes
Congenital (rare) - Choanal Atresia
Acquired:
Irritation from gastric reflux (e.g. Anesthesia)
Chronic inflammation
Brachycephalic Airway Obstructive Syndrome (BAOS) - Primary changes
Stenotic nares
Elongated soft palate
Thickening of soft palate
Macroglossia (Large tongue)
Distorted ethmoidal turbinates
Tracheal hypoplasia (Commonly associated with English bulldog)
Brachycephalic Airway Obstructive Syndrome (BAOS) - Secondary changes
Pharyngeal soft tissue thickening & subsequent obstruction
Everted laryngeal saccules
Laryngeal collapse
Brachycephalic Airway Obstructive Syndrome (BAOS) - Common concurrent lower respiratory tract disease
Bronchial collapse (Bronchomalacia)
*Tracheal hypoplasia can also be considered
Brachycephalic Airway Obstructive Syndrome (BAOS) - Common “Extra-respiratory” complication/clinical signs. Why does it happen and associated pathologies. How would you treat it?
Regurgitation & Vomiting
Increase in intra-thoracic negative pressure
Sliding hiatal hernia, Esophageal / Gastro-esophageal intussusception
1) Correct BAOS if possible (Might resolve GI clinical signs as well)
2) Metoclopramide +/- PPI
3) If clinical signs do not resolve /Gastro-esophageal intussusception is present - corrective surgery.
Brachycephalic Airway Obstructive Syndrome (BAOS) - Common clinical signs
Hyperthermia
Tachypnea
Exercise intolerance
Weight gain
Stertor, Stridor, Reverse sneezing
Cyanosis
Coughing (Tracheal +/- Bronchial involvement)
Syncope
Vomiting & Regurgitation
Anti-tussive drugs - 2 Contraindications
Bacterial pneumonia / bronchopneumonia
Bronchiectasis
What effects do organic phosphates have on the respiratory system?
Bronchoconstriction
Bronchorrhea (Increase in mucus production)
B2 Agonists - Side effects
Tachycardia
Muscle tremors/twitching
Hypokalemia (Translocation into the cells)
Hyperglycemia (Inhibits release of insulin)
Decrease Uterine Motility
MDI - Direct irritation and inflammation of airways
B2 Agonists - Effects
Potent bronchodilators
Inhibition of mast cell degranulation
Increase muco-ciliary clearance
Improved diaphragm function
Methylxanthines - Effects
Bronchodilators
Mast cell stabilization
Increased respiratory muscle strength
Increased muco-ciliary clearance
Decreased microvascular leakage
Methylxanthines - Side Effects
GI - Nausea/ Anorexia
Restlessness
Arrhythmias
Vasodilation
Diuresis
CNS signs
Glucocorticoides - Name 3 chronic LRT diseases that are treated with GCs
Canine & Feline Chronic Bronchitis
Feline Asthma
Eosinophilic Bronchopneumopathy
Steroids - Side effects (Clinical signs & Common lab-work findings)
Pu/Pd
Polyphagia
Panting
Dermal Changes
Muscle atrophy
Pot-belly
Obesity
2nd infections (e.g. Pyoderma, Cystitis)
CBC: Neutrophilia, Lympfhocytopenia, Polycythemia, Thrombocytosis
Biochem: Elevation of liver enzymes (primarily ALP in dogs), Hypertriglyceridemia, Hyperglycemia, Hypernatremia, Hypokalemia
UA: Isosthenuria, Proteinuria.
Steroids - Effects on the respiratory system& Preferred method of use (and name of the drug)
Decrease production of cytokines, PG and Leukotrienes
Reduce edema
Decrease granulocyte and lymphocyte migration & activity
Potentiate B2 agonists and mitigate down-regulation of B2 receptors
Metered dose inhaler (MDI) - Fluticasone (Less systemic side effects)
Mucolytics - Name, Mode of administration and why? Name 2 other alternatives to main drug
N-Acetylcystein
IV
Oral (Not nebulization - Causes Bronchoconstriction)
1) Maintain proper hydration (makes secretions less viscous)
2) Saline nebulization
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - Histological Changes
Decreased cellularity of cartilage
Increased water content
Decreased GAG, Glycoprotein, Chondroitin, Calcium
Laxity of dorsal tracheal membrane
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - Diagnosis (3 methods)
Chest X-Rays (Better for diagnosing TC»_space;» BM. In the case of BM - sensitivity is highest for Mainstem bronchimalacia and decreases further distally)
Fluoroscopy - (Better than X-rays. Better for TC and proximal airway collapse)
Endoscopy - Gold standard for both
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - When doing fluoroscopy - what is an additional diagnostic procedure you should always perform?
BAL (Broncho-alveolar lavage)
Tracheobronchomalacia has a strong association with bacterial infections.
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - What can make the disease suddenly clinical?
Obesity
Airway Inflammation/Infection
Intubation
Laryngeal Paralysis/Paresis
Airway Irritants
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - Treatment
1) Conservative / Medical approach (usually the preferred approach):
Switch from leash to harness
Promote weight loss
No extraneous exercise
Anti-tussives
Bronchodilators
GC (Short course to reduce inflammation)
*AB (if indicated for 2nd infection)
2) Surgical approach (in case medical approach fails, relevant only for TC):
-External prostheses (cervical trachea)
-Stents (cervical + thoracic trachea + proximal bronchi)
*Short course of GC + AB
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - Treatment of an acute episode (Rare)
ACP + Benzodiazepine
Anti-tussive (e.g. Butorphanol)
Bronchodilators
Oxygen - might help
Short term GC
Tracheobronchomalacia (Tracheal collapse & Bronchomalacia) - Signalment & Clinical Signs
Middle age to older dogs
BM - Generally large breeds and brachycephalic dogs (present in 88% of BAOS cases)
TM (AKA Tracheal collapse) - small breed dogs (Pomeranian over-represented)
Chronic disease
Hyperthermia
Tachypnea
Cyanosis
Exercise Intolerance
Weight gain
Cough
Crackles & Wheezes
Goose Honk (TM)
Syncope
Canine Infectious Tracheobronchitis (Kennel Cough) - Causative agents
Bordetella Bronchiseptica»»
Mycoplasma
Canine adenovirus
Parainfluenza
Calicivirus (Cat).
Canine Infectious Tracheobronchitis (Kennel Cough) - What are the 2 methods of vaccination? Onset of efficacy? Protection period
Bordetella Bronchiseptica:
1) Parenteral: 2 Injections 3-4 weeks apart, Effective 2 weeks after second shot
2) Intranasal - Starts working after 3 days. Single dose. Duration of immunity - 1 Year
*CAV, PI, Calicivirus - Core vaccinations
Canine Infectious Tracheobronchitis (Kennel Cough) - Treatment
A self limiting disease
If choosing to treat: Doxycycline (Drug of choice) / Azithromycin / Augmentin
Anti-Tussives
Fluids
Canine Infectious Tracheobronchitis (Kennel Cough) - Clinical signs
1) Nasal discharge without cough
2) Episodes of retching & coughing
Canine Infectious Tracheobronchitis (Kennel Cough) - Duration of Clinical signs without treatment & Duration of shedding
2 Weeks for clinical signs
2-3 Months of shedding