Veterinary Medicine - Oncology

Question 1

Small Cell Lymphoma - Treatment

Answer 1

Prednisone / Prednisolone (Cat), Chlorambucil

Question 2

Mast Cell Tumor - What are the common locations we can find metastasis?

Answer 2

Lymph nodes, Spleen, Liver

Question 3

Mast Cell Tumor - Treatment options (3)

Answer 3

Surgery, Tigilanol Tiglate (“Stelfonta”), Chemotherapy (e.g. Vinblastine, CCNU), Glucocorticoids, *Additional symptomatic treatment: H2 Receptor antagonists (e.g. Famotidine), PPI (e.g. Omeprazole), Anti-histamine (e.g. Diphenhydramine)

Question 4

Mast Cell Tumor - Tigilanol Tiglate (“Stelfonta”) - Indication

Answer 4

Cutaneous or sub-cutaneous mass below elbow or hock, No metastasis

Question 5

Lymphoma - Staging

Answer 5

Stage 1: Single lymph nodes Stage 2: Multiple lymph nodes on the same side of the diaphgram Stage 3: Multiple lymph nodes on both sides of the diaphgram Stage 4: Splenic / Hepatic involvement Stage 5: Bone-marrow / Blood involvement *Sub-stage: A (No clinical signs) / B (with clinical signsl

Question 6

Large Cell Lymphoma (B-Cell) - Common treatment protocol

Answer 6

L-CHOP: L-Asparginase | Vincristine Doxorubicin | Cyclophosphamide | Prednisone

Question 7

Mast Cell Tumor - Prognosis

Answer 7

Grade 3 / High - Months. Grade 1 / Low - 4-6 Years. Solitary mass with no lymph node metastasis - Excellent prognosis and surgery is often curative (Might need adjunctive chemotherapy depending on negative prognostic indicators) *Metastasis to local lymph node doesn’t necessarily worsen prognosis and depends on grading (As long as it is also removed). *Recurrence rate (1 year) - 10-30%. Hepatic / Splenic involvement - MST 4-6 Months

Question 8

Lymphoma - Prognostic indicators

Answer 8

Stage, Sub-stage (A vs. B), Grade (Histopathology), Immunophenotype (T-Cell vs. B-Cell), Small Cell Lymphoma vs. Large Cell Lymphoma, Specific locations (e.g. worse prognosis in primary hepatic, Cutaneous, Primary GI accompanied with clinical signs), Anemia, Hypercalcemia

Question 9

Large Cell Lymphoma (T-Cell) - Common treatment protocol

Answer 9

LOPP: CCNU | Procarbazine | Vinblastine | Prednisone

Question 10

What is the prognosis (& MST) For Feline GI Lymphoma - Small Cell and Large Cell? What about GI Lymphosarcoma in Dogs?

Answer 10

Large Cell - Grave. Small Cell - Much better - 1-1.5 years. GI LSA in dogs - Very poor

Question 11

Histiocytic Sarcoma - Common breeds

Answer 11

Bernese / Labrador / Golden Retriever / Min. Schnauzer / Corgi

Question 12

3 Most common hypercalcemia-causing Neoplasias

Answer 12

Anal Gland Adenocarcinoma, Mediastinal T-Cell Lymphoma, Histiocytic Sarcoma

Question 13

You suspect insulinoma b/c of hypoglycemia. What is a good follow up test to give you further proof?

Answer 13

Glucose / Insulin Ratio