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Dermatology > Vesicuar Skin lesions > Flashcards

Vesicuar Skin lesions Flashcards

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Dermatology Board Prep flashcards
1
Q

Where are the different locations of Blisters?

A

Subcorneal
Intraepidermal
Subepidermal

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2
Q

What are the different content types of Blisters?

A

Cell Poor

W/ inflammation

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3
Q

What is the procedure of biopsy for vesicular skin lesions?

A

Punch biopsy => Formalyn

Deeper biopsy for Ab Immunofluorescence

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4
Q

What are the traits of Bullous Pemphigoid?

A 
MOST COMMON bullous Auto Immune Dis
ONLY elderly
Evolves over wks -mon
NOT in mucosa
TENSE Bullae/erytematous skin
SUBEPIDERMAL BLISTER w/ EOSINOPHILS
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5
Q

What is Erythrodermic BP?

A

100% body erythema

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6
Q

What is the Tx of Bullous Pmphigoid?

A

Systemic Steroids/ immsupression
Permanent remission?
Can follow Serum Ab to BP180 and BP230

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7
Q

What is Cicatricial Pemphigoid?

A 
BP of mucosal surfaces
Chronic 
Scarring 
Tx immunosupressants 
Similar Histo to BP
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8
Q

What is Pemphigoid Gestationis?

A

Vesicuar eruption on abdomen
Can effect the baby
Can recur in sus pregnancies
White Females

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9
Q

What are the Traits of PUPP?

A 
Pruritic papules and plaques of preggo
Umbilical Sparing
In Striae
Dermatitis pathology
Negative DIF
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10
Q

What are the Traits of Pregnancy Prurigo?

A 
No blisters 
More coommon
Atopic Eruption of Preggo
Dermatitis Path
Neg DIF
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11
Q

What are the traits of Dermatitis Herpetiformis?

A

Extensor Inv: Elbows/knees
CELIAC DISEASE Tx: Dapsone
Pap, Ves, Bull on erematous or uticarial base

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12
Q

What is the PAthogenesis of Dermatitis Herpetiformis?

A

Ab to Tissue Transglutaminase

Granular IgA deposition in Dermal Papillae

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13
Q

What are the traits of Linear IgA Bullous Dermatosis?

A

Widespread vesicles and bullae
Clusters of jewels
Vancomycin induced LABD

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14
Q

What are the Traits of Porphyria Cutanea Tarda

A

Most Common

Sporadic associated with: Hemochromatisis, Hep C, Ethanol and Estrogens

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15
Q

What are the presenting features of PCT?

A

Blisters on light exposed skin

Tense Bullae on normal background

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16
Q

What is the Histo/DIF of PCT?

A

Cell poor Subepidermal blister

Superficial BV w/ circumferential IgG Deposition

17
Q

What is the Tx of PCT?

A

Avoid Ethanol and Estrogen
Phlebotomy (Iron)
LD Chloroquine

18
Q

What are the traits of Pemphigus Vulgaris?

A

AutoAb to IC layers of the Epidermis => Blistering from minor trauma
Chronic
Fatal if not Tx

19
Q

What is the Pathology of PV?

A

Auto Ab to Desmolegin 1/3

20
Q

What are the presenting features of PV?

A

Painful but not itchy
Oral mucosa
FLACCID VESICLES on NORMAL SKIN
Erode and Crust

21
Q

What is the Niklsky sign?

A

Dislodging of epidermis by lateral finger pressure near lesion => erosion

22
Q

What is the DIF apprearance of PV?

A

Cell surface IgG or C3

CHICKEN WIRE

23
Q

What is the Pathogenesis of Impetigo?

A

bacterial toxin that cleaves desmolegin 1 molecule (cell-cell adhesion w/in uppermost epidermal layers)

24
Q

What is the Histo of Impetigo?

A

Superficial blister w/ focal acantholysis

25
Q

What are the traits of Hailey-Hailey Disease?

A 
Benign Fam Pemphigus
Vesicles and bullae => crusting erosions 
Flexural and Intertriginous areas
Tx: Tetracycline
Ca Pump dysfunction
26
Q

What are the Traits of Darier’s Disease?

A

AD
Ca Pump dysfunction
Multiple discrete scaling papules in seborrheic distribution

27
Q

What are the Traits of Grover’s Disease?

A

W/ Heavy sweating or heat
Reddish small papules w/ vesicles and erosions
Tx: Topical Steroids or phototherapy

Dermatology (12 decks)

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