Vesicuar Skin lesions Flashcards
Where are the different locations of Blisters?
Subcorneal
Intraepidermal
Subepidermal
What are the different content types of Blisters?
Cell Poor
W/ inflammation
What is the procedure of biopsy for vesicular skin lesions?
Punch biopsy => Formalyn
Deeper biopsy for Ab Immunofluorescence
What are the traits of Bullous Pemphigoid?
MOST COMMON bullous Auto Immune Dis ONLY elderly Evolves over wks -mon NOT in mucosa TENSE Bullae/erytematous skin SUBEPIDERMAL BLISTER w/ EOSINOPHILS
What is Erythrodermic BP?
100% body erythema
What is the Tx of Bullous Pmphigoid?
Systemic Steroids/ immsupression
Permanent remission?
Can follow Serum Ab to BP180 and BP230
What is Cicatricial Pemphigoid?
BP of mucosal surfaces Chronic Scarring Tx immunosupressants Similar Histo to BP
What is Pemphigoid Gestationis?
Vesicuar eruption on abdomen
Can effect the baby
Can recur in sus pregnancies
White Females
What are the Traits of PUPP?
Pruritic papules and plaques of preggo Umbilical Sparing In Striae Dermatitis pathology Negative DIF
What are the Traits of Pregnancy Prurigo?
No blisters More coommon Atopic Eruption of Preggo Dermatitis Path Neg DIF
What are the traits of Dermatitis Herpetiformis?
Extensor Inv: Elbows/knees
CELIAC DISEASE Tx: Dapsone
Pap, Ves, Bull on erematous or uticarial base
What is the PAthogenesis of Dermatitis Herpetiformis?
Ab to Tissue Transglutaminase
Granular IgA deposition in Dermal Papillae
What are the traits of Linear IgA Bullous Dermatosis?
Widespread vesicles and bullae
Clusters of jewels
Vancomycin induced LABD
What are the Traits of Porphyria Cutanea Tarda
Most Common
Sporadic associated with: Hemochromatisis, Hep C, Ethanol and Estrogens
What are the presenting features of PCT?
Blisters on light exposed skin
Tense Bullae on normal background
What is the Histo/DIF of PCT?
Cell poor Subepidermal blister
Superficial BV w/ circumferential IgG Deposition
What is the Tx of PCT?
Avoid Ethanol and Estrogen
Phlebotomy (Iron)
LD Chloroquine
What are the traits of Pemphigus Vulgaris?
AutoAb to IC layers of the Epidermis => Blistering from minor trauma
Chronic
Fatal if not Tx
What is the Pathology of PV?
Auto Ab to Desmolegin 1/3
What are the presenting features of PV?
Painful but not itchy
Oral mucosa
FLACCID VESICLES on NORMAL SKIN
Erode and Crust
What is the Niklsky sign?
Dislodging of epidermis by lateral finger pressure near lesion => erosion
What is the DIF apprearance of PV?
Cell surface IgG or C3
CHICKEN WIRE
What is the Pathogenesis of Impetigo?
bacterial toxin that cleaves desmolegin 1 molecule (cell-cell adhesion w/in uppermost epidermal layers)
What is the Histo of Impetigo?
Superficial blister w/ focal acantholysis
What are the traits of Hailey-Hailey Disease?
Benign Fam Pemphigus Vesicles and bullae => crusting erosions Flexural and Intertriginous areas Tx: Tetracycline Ca Pump dysfunction
What are the Traits of Darier’s Disease?
AD
Ca Pump dysfunction
Multiple discrete scaling papules in seborrheic distribution
What are the Traits of Grover’s Disease?
W/ Heavy sweating or heat
Reddish small papules w/ vesicles and erosions
Tx: Topical Steroids or phototherapy
