Benign Skin Tumors Flashcards by Scott Meteer

What are the traits of Seborrheic Keratoses?

Round, flat, coin like, waxy plaques. Pigmented or non

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What is the Tx of Seborrheic Keratoses?

Surgery
Chemical Peeling Agents
Electrocautery
Cryotherapy
Only if bothersome

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What is the Lesser Trelat Sign?

Numerous SK indicating visceral malignancy

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What is a Fibroepithelial Polyp-Acrochordon?

Fibrovascular core covered by benign squamous epithelium (skin tags)

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List the types of Epithelial Cysts?

Epidermal Inclusion cysts
Pilar or trichilemmal cysts
Dermoid Cysts
Steatocystoma multiplex

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What are the traits of Epidermal Inclusion cysts?

Filled loosly w/ Keratin

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What are the traits of Trichilemmal cysts?

Filled tightly w/ keratin

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What are the traits of Dermal cysts?

Subcutaneous nodule at birth on lateral aspect of upper eyelid

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What are the traits of Steatocystoma multiplex?

AD mutation in Keratin 17

Sternal, axillae, groin

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What are the traits of Trichilemmoma and cowden’s disease?

Solitary

Cowden’s: AD, mutation of tumor supressor PTEN

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What are the traits of Pilomatrixoma?

Solitary firm nodule on head, upper limbs, neck, trunk

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What are the traits of Birt-Hogg-Dube Syndrome?

Mutation of BHD gene on chromosome17
Multiple microfolliculomas
Fibrofolliculoma**
Trichodiscoma**

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What are the traits of Nevus Sebaceous?

Head/neck, scalp.

Benign but 2^ tumor can arise within

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What are the traits of Sebaceous Hyperplaia?

Face of older adults
Mis-dx as BCC
Yellowish dome shaped papules

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What are the Traits of Sebaceous Adenoma?

Muir-Torre Syndrome

Face and scalp of older people

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What are the traits of Muir-Torre Syndrome?

Related to HNPCC (DNA mismatch repair) AD

MSH2 gene mutated

What are the findings in MTS?

Sebaceous tumors

GI, Bladder, Endometrial, Breast Cancer

How is MTS Diagnosed?

Immunostaining for mismatch repair Ez

Followup w/ genetic sequencing

What are the traits of Cylindroma?

Pink/red nodule
Brook-Spiegler synd
F:M 9:1
Turban tumor
Jigsaw puzzle epithelial cells

What are the traits of Xanthomas?

Aggregate of Histiocytes w/ cytoplasmic lipid

What are the 5 types of Xanthomas?

Eruptive, Tendinous, Tuberous, Planar, Disseminated

What are the traits of Xanthogranuloma?

Yellow/Brown/orange papule or nodule
Accoc w/ CML and NF
Regresses

What are the traits of Reticulohistiocytoma?

Solitary or multicentric reticulohistiocytosis

Ground glass histiocytes

What are the traits of Langerhans Cell Histiocytosis?

Proliferation of Lang cell type histiocytes in tissue

What is the Most aggressive form of LCH?

Acute Generalized LCH | High M and M

What are the Traits of Lipomas?

Most common connective tissue tumor | Benign. Excision is curative

What are the traits of Traumatic neuromas?

Peripheral n severed and doesn't heal | Disorderly proliferation

What are the traits of Morton's neuromas?

Pain of sole of foot Region of metatarsal heads Walking makes it worse

What are the traits of Mucosal neuromas?

MEN 2b Need genetic testing and Thyroid imaging Multiple and clustered around the mouth

What are the traits of Palisaded Encapsulated Neuroma?

Solitary painless nodule | Face most common site

What are the traits of a Schwannoma?

Hyalinized Vessels Antoni A and B Prominent BV

What are the traits of Neurofibroma?

Solitary Polypoid or nodular lesion | Plexiform = NF-1

What are the traits of Giant cell tumors of the Tendon sheathe?

Hands/Feet/wrists/knees | Nodular Tenosynovitis

What are the traits of Ganglion cysts?

Myxoid Degen of joint capsule or tendon sheathe 2^ to injury or overuse Cystic space lined w/ histiocytes and gran tissue Mucin pockets

What are the traits of Superficial Firomatosis?

Hand- Dupuytren contrcture Penile Plantar Not assoc w/ Beta-catenin mutations