SCC/BCC Flashcards
What are the traits of Basal Cell CA?
Rarely Mets
Local aggresion and tissue destruction
SUN EXPOSURE
Pearly Papules cont prominent dilated SubEpi BV
What is the Tx of BCC?
Excision/Destruction Small: Cryo/Electrosurg Topical Radiation Moh's Surgery
What is Moh’s Surgery?
Micro Control for lesions in anatomically sensitive areas
What is the pathology of BCC?
Nodules attached to the Dermis. Cells line up along nodules. (Along Derm/Epiderm border)
What are the traits of Gorlin Syndrome?
AD
Mutation of PTCH Gene on Chromosome 9 (tumor supressor- mutation allows SHH => Cell growth)
What are the Causes of Squamous Cell CA?
Caused by UV exposure, HPV, Carcinogens, Chron, ulcers
IMMUNOSUPRESSION
What are the Traits of SCC?
Associated with Actinic Keratosis Firm Hyperkeratotic Plaque Can have Erosions and Crusts Locally Destructive CAN Mets
SCC in ___________ are most likely to mets.
Ear, Lip, Genitalia
What is the Tx of SCC?
Excision- Mohs in diff site
Radiation if surgery not sucessful/Feasable
What is the Path of SCC?
Proliferation of the Spinous layer of the epidermis
What are the Prognostic facotrs of SCC?
Size >4cm
Depth of invasion
Neurotropism
Acantholytic PAttern
What are the Traits of Verrucous CA?
Low Grade/ Well Diff variant
Sole of Foot most common
(Sinus Tract?)
What are the traits of Anogenital Verrucous CA?
Condyloma Accuminata
HPV related (6 and 11)
Difficult to comtrol
What are the traits of Keratoacanthoma?
Rapildy Devt Neoplasm
Mimics SCC
Flesh colored, dome shaped nodules with central keratin filled plug. Crater like
What is the Tx of Keratocanthoma?
Surgical Excision
What are trhe Traits of Actinic Keratosis?
Squamous Dysplasia (Buildup of Excess keratin)
What is the management of AK?
Prev w/ sunscreen! Cryosurgery 5-FU Topical Retinoids Facial Peels Follow-up w/ monitoring for SCC
What are the Traits of Bowenoid Papulosis?
Variant of SCCIS Anogenital, HPV related Young SA Adults Small reddish brown papules Histo ID to Bowen's
WHat are the Traits of Xeroderma Pigmentosum?
AR
Sun sensitivity- Sunburn w/ min exposure
What is the PAthophys of Xeroderma Pigmentosum?
Mult genetic Defects
Can’t repair DNA damage from UV radiation
What are the Traits of Merkel Cell CA?
Resembles Mets SCC
What are the cancers that Most commonly mets to the skin?
Lung Colon Melanoma Oral SCC Females: BREAST (69%)
What is a sister MAry Joseph Nodule?
Cancer in the Umbilicus a sign of cancer of the abdomen
What are the Traits of Mammary Paget’s Disease?
Associated with Mammary Ductal CA
Mistaken for Eczema or psoriasis
