Venous Disease including Chronic Ulcers Flashcards

1
Q

What is chronic venous disease?

A

Venous return impaired > sustained venous hypertension

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2
Q

What is telangiectasia?

A

Small dilated vessels

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3
Q

How can fusion of the ankle cause calf muscle pump failure?

A

Can’t dorsiflex and plantarflex > calf muscle pump doesn’t work

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4
Q

Where are you more likely to have a deep vein thrombosis: in the superficial or deep system?

A

Deep system, especially below knee

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5
Q

What do the perforating veins in the legs do?

A

Join superficial and deep system

Functional valves prevent reflux from deep to superficial to deep

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6
Q

What is the white cell trapping hypothesis?

A

WBCs larger and less deformable than RBCs
When perfusion pressure reduced by venous hypertension, WBCs plug capillaries and RBCs build up behind
WBC activation
Endothelial adhesion by WBCs release proteolytic enzymes and oxygen free radicals > endothelial and tissue damage

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7
Q

What is the fibrin cuff hypothesis?

A

Increased venous pressure directly transmitted to capilllaries > capillary elongation and increased endothelial permeability
Larger molecules like fibrinogen become deposited into tissues > fibrin
Accumulation of fibrin acts as barrier to oxygen > tissue hypoxia > ulceration

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8
Q

What is CEAP classification?

A
Standardises severity of venous disease
C - clinical classification
E - aetiological classification
A - anatomic classification
P - pathophysiological classification
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9
Q

How do you differentiate between venous and arterial pain in the leg?

A
Venous
- To relieve pain, have to elevate leg
- Takes 20 min
Arterial
- If pain after exercise > rest
- If pain at rest > dangling leg (use gravity)
- Takes 5 min
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10
Q

What are varicose veins?

A

Elongated, tortuous, dilated veins

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11
Q

What are primary varicose veins?

A

Affecting superficial/perforating veins in absence of deep incompetence

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12
Q

What are secondary varicose veins?

A

Associated with deep venous incompetence from recanalisation of previous deep vein thrombosis
Venous obstruction

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13
Q

What can cause a venous obstruction, leading to secondary varicose veins?

A
Mechanical obstruction
- Big gut
- Big hernia
- Pregnancy
Vein thrombosis
Orthopaedic injuries
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14
Q

What are the risk factors for chronic venous disease?

A

Genetics

Previous deep vein thrombosis

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15
Q

What is the clinical presentation of chronic venous disease?

A
Cosmetic
Pain
Swelling
Thrombophlebitis
Bleeding
Skin changes
Ulceration
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16
Q

What is thrombophlebitis?

A

Inflammation of vein wall with associated thrombosis

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17
Q

What cosmetic issues can patients present with?

A

Telangiectasia
Reticular veins
Varices

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18
Q

What sort of pain do patients complain of?

A

General leg ache/heaviness

Venous claudication

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19
Q

What sort of swelling can patients present with?

A

Early ankle pitting oedema

Later becomes indurated

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20
Q

What sort of skin changes can patients present with?

A

Varicose eczema
Pigmentation
Lipodermatosclerosis
Atrophie blanche

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21
Q

What does lipodermatosclerosis often look like?

A

Inverted champagne bottle

  • Narrow ankle
  • Bulging leg higher up
22
Q

What should you do if you see a red leg?

A

Don’t assume red leg = cellulitis

Look for other signs of infection

23
Q

What is atrophie blanche?

A

Confluence of white, depressed scars

24
Q

What investigations are done in chronic venous disease?

A

Venous duplex

Descending venography

25
What is the conservative treatment of chronic venous disease?
``` Elevate legs - Not ideal in long-term management Avoid standing still - Not ideal in long-term managemt Dressings for ulceration Graduated compression stockings ```
26
Who are class 1 compression stockings good for?
People with early venous disease Preventative; eg: after ankle fusion Possibly for some elderly patients because many can't put on tighter socks
27
What sort of treatment is going to fix the underlying problem in chronic venous disease?
Surgery
28
What is sclerotherapy?
Inject something to shut down vein Done under ultrasound Less invasive
29
What surgical treatments are available for chronic venous disease?
Sclerotherapy Open surgery Endovenous laser therapy Radiofrequency ablation
30
95% of ulcers are of what type?
Ischaemic Neuropathic Stasis/venous Can be mixed aetiology
31
What other causes of ulcers are there?
``` Infective - Syphilis - Mycobacterium - Osteomyelitis Neoplastic - Squamous cell carcinoma - Basal cell carcinoma - Melanoma - Metastatic - Kaposi's sarcoma Systemic disease - Pyoderma gangrenosum Traumatic - Thermal burns - Radiation - Bites ```
32
What is pyoderma gangrenosum?
Condition causing tissue to become necrotic, causing deep ulcers on, usually on legs
33
How do you identify ischaemic ulcers on history?
Painful - but not always; eg: if have severe neuropathy History of claudication/rest pain Cardiovascular risk factors Previous peripheral vascular surgery
34
How do you identify ischaemic ulcers on exam?
Location - Distal periphery - Over dorsum of foot/pretibia Punch-out edges = clearly demarcated edge, quite deep Ulcer base = poorly developed grey granulation tissue Surrounding skin pale/mottled with no signs of inflammation Little bleeding when debrided - Slow weeping bleed
35
What are the signs of chronic arterial insufficiency?
``` Atrophic nails/skin Venous guttering Slow capillary return Absent pulses Beurger's positive ```
36
What is Beurger's sign?
``` Elevate leg Drop legs (both for comparison) Bright rubor of skin as blood returns to limb ```
37
How does red ischaemic skin feel in temperature?
Usually cooler > compare to area on contralateral limb
38
How do you identify neuropathic ulcers on history?
Painless - May not feel pain directly - If neuropathic person suddenly feels pain > most likely deep tissue infection History of diabetes/other causes of neuropathy
39
Other than diabetes, what are the causes of neuropathy?
``` Alcohol Stroke Myesthenia gravis Illicit drug use Chemotherapy HIV Syphilis Multiple sclerosis Congenital Sometimes severe B12 deficiency ```
40
How do you identify neuropathic ulcers on exam?
``` Deep Location: pressure points/calluses - Plantar surface of metatarsophalangeal joints - Bunion/bunionette areas - Dorsum of interphalangeal joints - Base of 5th metatarsal - Callused posterior rim of heel pad Signs of neuropathy - Hypoaesthesia - Proprioception - 2-point discrimination - Vibratory perception Features of distorted foot architecture - Hyperextension of metatarsophalangeal joints - Hyperflexion of interphalangeal joints - Charcot's deformity ```
41
Why does distorted foot architecture lead to ulcers?
Because of motor neuropathy Small muscles of foot become weaker Larger muscles deform foot Loss of muscle bulk > loss of padding in foot
42
How do you identify venous ulcers on history?
``` History of venous insufficiency? - Varicose veins - Superficial thrombophlebitis/deep vein thrombosis - Variceal bleeding Previous venous surgery ```
43
How do you identify venous ulcers on exam?
``` Larger and irregular edge Shallow Location: over gaiter area - Commonly medial malleolus Moist granulating base Surrounded by zone of inflammation and stasis dermatitis Associated signs of venous insufficiency ```
44
What is the gaiter area?
Lower part of leg, above ankle
45
What are the signs of venous insufficiency?
``` Varicose veins Pitting oedema Varicose eczema Pigmentation Lipodermatosclerosis Atrophie blanche ```
46
What investigations can be done for ulcers?
``` Blood tests Swab X-ray +/- bone scan +/- MRI Duplex CT angiography Digital subtraction angiography Punch biopsy ```
47
What blood tests can be performed for ulcers?
``` Full blood exam Urea and electrolytes CRP Glucose HbA1c Vasculitis screen ESR Thrombophilic screen ```
48
How do you get a good swab of an ulcer?
Clean wound | Get to red area
49
What is more accurate: a swab, or a punch biopsy?
Punch biopsy
50
What is the treatment for ulcers?
``` Bed rest Elevation/dependency IV antibiotics Dressings Debridement Treat underlying aetiology - Try and do this first otherwise management won't work ```