Stroke and TIA Flashcards

1
Q

What is the second leading cause of death worldwide?

A

Stroke

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2
Q

What is dysphasia?

A

Language disorder
Deficiency in generation of speech
Sometimes also comprehension
Due to brain disease/damage

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3
Q

What is expressive dysphasia?

A

Difficulty in putting words together to make meaning

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4
Q

What is receptive dysphasia?

A

Difficulty in comprehension

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5
Q

What is dysarthria?

A

Speech disorder caused by disturbance of muscular control

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6
Q

What is dysphonia?

A

Difficulty speaking due to physical disorder of

  • Mouth/
  • Tongue/
  • Throat/
  • Vocal cords
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7
Q

What does the acronym FAST stand for?

A
F - facial weakness
- Can person smile
- Has mouth/eye drooped
A - arm weakness
- Can person raise both arms?
S - speech difficulty
- Can person speak clearly and understand what you say?
T - time to act fast
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8
Q

Why is it important to know the exact time of onset of symptoms in stroke?

A

Because treatment available very time critical

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9
Q

How can you assess facial droop?

A

Asymmetry in nasolabial folds

If subtle, get patient to smile

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10
Q

What type of lesion is indicated if the upper half of the face is spared?

A

Upper motor neuron lesion on contralateral side

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11
Q

What type of lesion is indicated if the whole half of the face is affected?

A

Lower motor neuron lesion on ipsilateral side

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12
Q

How can arm drift be used to assess weakness in an arm in the assessment of a possible stroke?

A

Ask patient to close eyes and hold out both arms, palms facing up
Arm on weaker side pronates and drifts downwards

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13
Q

What type of dysphasia Broca’s dysphasia?

A

Expressive

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14
Q

What type of dysphasia is Wernicke’s dysphasia?

A

Receptive

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15
Q

What is a silent stroke?

A

May not have much of deficit
May be difficult to elicit deficit if present even 1 hour later
Still have tissue infarction on imaging

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16
Q

Define stroke

A

Brief episodes <24 hours with brain injury

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17
Q

Define transient ischaemic attack (TIA)

A

Brief neurological episodes, usually <24 hours, without damage on imaging

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18
Q

What does a code stroke in the emergency department mean?

A
Urgent triage and high priority
Mobilise stroke team
IV
- Glucose
- Routine biochemistry
- Full blood exam (FBE)
ECG
Accurate clinical diagnosis
- Exclude mimics
Urgent CT
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19
Q

Why is blood glucose measured in a possible stroke patient?

A

Hypoglycaemia = great mimic, especially of stroke

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20
Q

Why is an FBE performed in a stroke patient?

A
Platelet levels
- If known coagulopathy
- On anticoagulant
Include INR
Both assess risk of bleeding because of thrombolysis
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21
Q

Why is a CT scan performed?

A

To exclude haemorrhage
Doesn’t matter if you accidentally thrombolyse a TIA/stroke mimic
- But important not to thrombolyse haemorrhage

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22
Q

When does thrombolysis lose its benefit-to-risk ratio?

A

After 4.5 hours

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23
Q

How do you predict a stroke has occurred, and not a mimic?

A
Exact time of onset
Patient could recall exactly what they were doing when symptoms started
Well in last week
Definite focal symptoms/signs
Worse NIH stroke score (NIHSS)
24
Q

How do you predict a mimic has occurred, and not a stroke?

A
Known cognitive impairment
Lost consciousness/seizure at onset
Patient could still walk
No lateralising symptoms
Confusion
Non-vascular, or no neurological signs
25
Does a CT scan help in the diagnosis of a stroke?
No, remains clinical diagnosis Scan done only to exclude haemorrhage Signs of infarct can take up to 72 hours to develop
26
What are the three major stroke types?
Ischaemic stroke = cerebral infarction Intracerebral haemorrhage Subarachnoid haemorrhage
27
What are the common types of ischaemic stroke?
``` Large artery thromboembolism Cardiogenic embolism Small vessel (lacunar) infarction Rarer causes Unclassified/cryptogenic ```
28
What are the common types of intracerebral haemorrhage?
Deep hypertensive location | Lobar
29
What are the common types of subarachnoid haemorrhage?
Aneurysm Arteriovenous malformation Other
30
What is a larger artery thromboembolism?
Cortical infarction More than 50% relevant large artery stenosis Absence of cardiac source
31
What is a cardiogenic embolism?
Cortical infarction Cardiac source Absence of large artery disease
32
What is the most common cardiac source of a cerebral infarction?
Atrial fibrillation
33
What is a lacunar infarction?
Subcortical infarction Absence of large artery/cardiac source Clinical syndromes
34
What are some rare causes of ischaemic stroke?
Arterial dissection Drugs Vasculitis Rarer arteriopathies; eg: Moyamoya disease
35
What is the most lethal stroke subtype?
Haemorrhage
36
What is a deep intracerebral haemorrhage?
``` Putamen Thalamus Brainstem Cerebellum Usually due to hypertension and rupture of deep penetrating arteries ```
37
What is a lobar intracerebral haemorrhage?
``` Superficial Often secondary to - Amyloid angiopathy - Tumour - Arteriovenous malformation - Aneurysm ```
38
What does stroke evolution result in?
Increased lesion volume > worse outcome
39
What is the aim of therapies for ischaemic stroke and intracerebral haemorrhage?
Limiting stroke growth
40
What is IV tPA?
Thrombolytic
41
What is hemicraniectomy?
Skull flap removed for some days, allowing swelling to subside
42
What are the non-modifiable risk factors for ischaemic stroke?
``` Age Gender Family history Ethnicity Contraceptive use ```
43
What are the established modifiable risk factors for inschaemic stroke?
``` Hypertension Diabetes Smoking Atrial fibrillation/heart disease Hypercholesterolaemia Alcohol consumption Prothrombotic factors Prior TIA Prior stroke ```
44
What are the possible modifiable risk factors for ischaemic stroke?
``` Physical inactivity Obesity Dietary factors Infection Stress Sleep apnoea Socioeconomic status ```
45
What are the main modifiable risk factors for ischaemic stroke?
Smoking Hypertension Diabetes Obesity
46
Do antihypertensive drugs reduce the risk of primary stroke?
Yes, by 40%
47
Is there an indication for antiplatelet treatment in ischaemic stroke?
No clear indication in low-intermediate risk | In high risk, consider aspirin
48
Does warfarin decrease the risk of stroke?
Yes
49
What are the classes of the new oral anticoagulants?
Direct thrombin inhibitor | Factor Xa inhibitors
50
What is the drug class of dabigatran?
Direct thrombin inhibitor
51
What is the drug class of rivaroxaban?
Factor Xa inhibitor
52
What is the drug class of apixaban?
Factor Xa inhibitor
53
What is the advantage of the new oral anticoagulants over warfarin?
Less likely to cause intracerebral haemorrhages
54
What is the CHADS2 scoring system?
Measure for calculating risk of haemorrhage
55
How is secondary prevention carried out in stroke?
Tailored to stroke pathogenesis in individual
56
When should secondary prevention for stroke start?
In hospital
57
Describe in general terms the secondary prevention of stroke
``` Lower blood pressure Control cholesterol with statins Antiplatelet therapy Control atrial fibrillation with anticoagulation Carotid revascularisation - Endarterectomy - Stenting ```