VDs Flashcards
side effects of VDs
arterial pressure reduction Tachycardia
orthostatic hypotension
↑renin secretin water retention
Treatment of acute anginal episode?
Prevention option?
NTG and Isosorbide dinitrate for treatment
Isosorbide mononitrate for prevention
What drug class work mainly on heart myocytes?
Verapamil and Diltiazem
What drug class work mainly on smooth muscle (vessels)
Dihydropyridines
Nicorandil MoA
Potassium channel opener
slows firing
+
Nitrate group in it
Effect of vasodilators
Decrease after-load and increase preload —- Enhance cardiac output
What are the organic nitrates drugs
Nitroglycerin
Isosorbide dinitrate
Isosorbide mononitrate
Name of the enzyme that metabolize nitrates
Nitrate reductase
What are Calcium channel blocker drugs
Dihydropyridines
Phenalkylamines-VERAPAMIL
Benzothiazepines- DILTIAZEM
Adverse effects of ON
Headache
Dizziness, NV, RTachycardia
Tolerance
Adverse effects of Nicorandil
Headache
Dizziness, Palpation
GIT
postural Hypotension
Adverse effects of CCBs
- Cardiac depression “bradycardia, AV block, and heart failure”
- Flushing, dizziness, nausea, peripheral oedema, and headache
- Reflex tachycardia specially with dihydropyridines
- Constipation
