Brainscape's Knowledge GenomeTM

Browse over 1 million classes created by top students, professors, publishers, and experts.


See full index

Pharmacology > Agents used in cardiac arrhythmias > Flashcards

Agents used in cardiac arrhythmias Flashcards

1
Q

Ivabradine MoA

A

Selective inhibition of funny channels in SA node, to slow its firing , and ↓HR
(Prolong the drift)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
2
Q

Two adverse effects of Ivabradine

A

Bradycardia

Visual disturbance

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
3
Q

What is the mechanism of action of class one drugs

A

Modulate or inhibit sodium channels prolong phase 0

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
4
Q

What is the mechanism of action of Quinidine Ia

A

Sodium channel blocker slow activation (firing)

Potassium channel blocker (Prolongs action potential)

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
5
Q

Adverse effects of Quinidine

A 
Conduction disturbance (slow)
Pro  arrhythmia and ventricular arrhythmia
Hypotension
Hypoglycemia
NV
Cinchonism
Immune-mediated reactions

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
6
Q

Mechanism of action of Lidocaine

A

Sodium channels blockade (Phase 3 shortens repolarization) + K (weak)
Have central nervous system effects

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
7
Q

Mechanism of action of Flecainide 

A

 sodium channel blocker
Potassium channel blocker
Slows phase zero

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
8
Q

Adverse effects of Flecainide

A

Malignant arrhythmia (use only fir healthy hearts)

Dizziness, blurred vision, headache

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
9
Q

What are the class two drugs

A

Propranolol

Sotalol

B1 blockers

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
10
Q

Where is the mechanism of action of class two drugs

A

They inhibit the sympathetic activity

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
11
Q

What are the class three drugs and their mechanism of action

A

Amiodarone
Potassium channel blocked
Prolongs the repolarization phase (phase 3)


How well did you know this?
1
Not at all
2
3
4
5
Perfectly
12
Q

What are the adverse effects of amiodarone

A 
Pulmonary toxicity
Thyroid dysfunction
Bradycardia AV block QT PRONLONGATION
Hepatitis
Skin reaction blue man syndrome photosensitivity
Tear deposits
How well did you know this?
1
Not at all
2
3
4
5
Perfectly
13
Q

What is the mechanism of action of verapamil

A

Ca+ Channel blocker slows firing

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
14
Q

Quinidine + Procainamide

A

Na channel blockade
Depress phase 0 depolarization Slows conduction
K channel blockade
Prolongs action potential duration “APD” and ↑ERP

Sites: As+Vs

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
15
Q

Clinical uses of Amiodarone

A

atrial arrhythmias

paroxysmal atrial fibrillation

pharmacologic cardioversion of AF

Prevention of postoperative atrial fibrillation and atrial flutter

Prevention of implantable cardioverter defibrillator (ICD) shocks

Secondary prevention of sudden cardiac death

How well did you know this?
1
Not at all
2
3
4
5
Perfectly
16
Q

Adverse effects of Amiodarone

A

Pulmonary toxicity (pneumonitis)

Thyroid dysfunction

Cardiac toxicity; bradycardia, AV blocks, QT prolongation

Hepatitis

Skin reactions: photosensitivity or blue-man syndrome

Corneal micro-deposits

17
Q

Ivabradine class 👙

A

hyperpolarization-activated cyclic nucleotide-gated channels blocker

18
Q

What drug causes QTprolongation

A

Quinidine

19
Q

What drugs have a hypotension effect working on A adregenic receptor

A

Quinidine

20
Q

Drug that shortens phase 3 repolarization (Atrium, Ventricle)

A

Lidocaine

21
Q

What drugs markedly slow phase 0 depolarization

A

Flecainide

22
Q

What drug prolong phase 4 repolarization (Atrium Ventricle)

A

Amiodarone

23
Q

What drug causes dry cough

A

Amiodarone

24
Q

Verapamil and diltiazem moa

A

Slows phase 4 SA AV

Pharmacology (11 decks)

Brainscape helps you reach your goals faster, through stronger study habits.
© 2024 Bold Learning Solutions. Terms and Conditions