Drugs For Gout Flashcards
What NSAIDs are used for acute gout
Indomethacin and naproxen
What are COX2 inhibitors used for acute gout?
Etoricoxib
Colchicine
What corticosteroid is used for treatment of acute gout?
Prednisone
Treatment of acute gout?
NSAIDs
Corticosteroids
IL-1 inhibitors (canakinumab or Anakinra)
Drugs used for chronic gout
Allopurinol probenecid febuxostat pegloticase 
Mechanism of action of Allopurinol
inhibits the biosynthesis of uricNacid (metabolite of purines) by inhibiting xanthine oxidase
Colchicine MoA
Anti inflammatory by:
Inhibit inflammasome NLP3
Inhibits E-selectin on endothelial cells and prevent neutrophils adhesion
Inhibits IL-1 and IL-8 and superoxide release from neutrophils
also inhibits protein tubulin —— prevent polymerization
Side effects of colochicine
Diarrhea
abdominal pain
vomiting
Renal disfunction
hepatic necrosis
seizures
What corticosteroid are used as intra-articular injection
Triamcinolone
What drugs are used as a long-term management
Probenecid
benzbromarone
sulfinpyrazone
Mechanism of action of Uricosuric agents
inhibit reabsorption of uric acid and enhance renal secretion by blocking active transporters in the proximal tubule.
Toxicity with Allopurinol
GI intolerance
peripheral neuritis
necrotizing vasculitis
bone marrow suppression
rarely aplastic anemia.
What is Pegloticase
recombinant DNA-produced form of the porcine enzyme uricase that metabolizes urate to allantoin, an inert and water-soluble purine metabolite rapidly cleared by the kidney.
