Pharmacogentics

Question 1

Phase I Enzymes function

Answer 1

modify functional groups e.g. (−OH,-SH, −NH2, −OCH3)

Question 2

Phase II Enzymes function

Answer 2

conjugate endogenous molecules, eg, sulfuric acid, glucuronic acid, and acetyl CoA, onto a wide variety of substrates in order to enhance their elimination from the body.

Question 3

Hydralazine

Answer 3

N-acetyl transferase*

PM- Lupus erythematosus like RASH

Question 4

Codein (Enzyme, effect)

Answer 4

CYP2D6
Em- sufficient pain relief
PM,IM- PAIN
UM- Toxicity

Question 5

Clopidogrel (Enzyme, effect)

Answer 5

(Prodrug)
CYP2D16
PM- thrombotic event

Question 6

Succinylcholine (Enzyme, effect)

Answer 6

PseudoCholinesterase

PM- muscle paralysis, cyanosis- death

Question 7

Fluorouracil

Answer 7

DHPD

PM- Toxcity

Question 8

Isoniazid (Enzyme, effect)

Answer 8

N-Acetyl transferase
EM- hepatotoxicity
PM- Peripheral neuropathy

Question 9

Hydralazine (Enzyme, effect)

Answer 9

N-acetyl transferase

PM- rash

Question 10

Bilirubin (Enzyme, effect)

Answer 10

Glucuronyl transferase

Hyperbiliribinemia [gilbert syndrome]

Question 11

Irinotecan (Enzyme, effect)

Answer 11

Glucuronyl Transferase

PM- toxicity