ANS 4

Question 1

Natural Belladonna Alkaloids drugs

Answer 1

Atropine
Hyoscine
Scopolamine

Question 2

Synthetics drugs

Answer 2

Ipratropium 
Oxybutynin 
Darifenacin
Dicyclomine
Homatropine

Question 3

Effects of (M) Cholinoceptor Blockers (Antagonists) on CNS

Answer 3

Sedation
drowsiness
amnesia
anti-motion sickness action
anti-Parkinsons’ action

Question 4

Effects of (M) Cholinoceptor Blockers (Antagonists)
On Eye

Answer 4

Cycloplegia, mydriasis

Question 5

Effects of (M) Cholinoceptor Blockers (Antagonists) Bronchi

Answer 5

Bronchodilation, especially if already constricted due to a disease Inhibition of bronchial secretions

Question 6

Effects of (M) Cholinoceptor Blockers (Antagonists) GIT

Answer 6

Relaxation, slowed peristalsis, reduced salivation

Question 7

Effects of (M) Cholinoceptor Blockers (Antagonists) UT

Answer 7

Relaxation of bladder wall, urinary retention

Question 8

Effect on heart

Answer 8

Bradycardia then Tachycardia

Question 9

Effect on blood vessels

Answer 9

No effect unless a muscarinic agonist is present; block of muscarinic vasodilation

Question 10

Mydriasis, cycloplegia during ophthalmologic examination

Answer 10

Homatropine

Question 11

Motion sickness

Answer 11

Scopolamine patch [hyoscine]

Question 12

Synechiae (eye disease)

Answer 12

Atropine

Question 13

As pre-anesthetic agents to inhibit salivation, respiratory

tract secretions

Answer 13

Hyoscine

Question 14

GIT cramps or Irritable bowel syndrome [gas, bloating]

.

Answer 14

Hyoscine, dicyclomine

Question 15

Diarrhea [Traveler’s diarrhea]

Answer 15

Hyoscine, dicyclomine, atropine

Question 16

Overactive bladder

Answer 16

Oxybutynin, darifenacin

Question 17

bronchodilators in asthma and COPD

Answer 17

Ipratropium

Question 18

Poisoning by anti-cholinesterase inhibitors (e.g. organophosphates, insecticides, chemical warfare “nerve gases”)

Answer 18

Atropine (non-selective); Pralidoxime can be used.

Question 19

Bradycardia [M2 receptors]

Answer 19

Atropine

Question 20

Mushroom poisoning

Answer 20

Atropine

Question 21

Side effects of M bloackers

Answer 21

At moderate dose: 
dry mouth
dry eyes
blurred vision (mydriasis),
constipation
difficulty urination
hyperthermia
At higher dose:
					CNS toxicities: 
									sedation, 
									amnesia, 
									delirium, 
									hallucination, 
									psychosis,
									convulsion, 
									coma.
					CVS toxicities: flushing, 
									dilatation of cutaneous vessels (arm, head, neck),
									tachycardia, 
									cardiac arrest.