HeartFailure Drugs Flashcards
Inotropic Drugs Classification
Cardiac glycosides: Digoxin
Bipyridines [Milrinone]
Dopamine + Dabutamine
ACE inhibitors Drugs
Captopril
Enalapril
Beta blocker Drugs
Carvedilol
bisoprolol
Metoprolol
Diuretics drugs
Furosemide (stronger)
thiazides
Aldosterone antagonists:
Spironolactone
vasodilators:
Hydralazine more arteriodialation
nitroglycerin more venodialation
Mechanism of action of Digoxin
Inhihbits membrane bound Na+ K+ ATPase
Increase Na+ level inside the cell
Reduced Na+ -Ca+ exchange- ca+ efflux out of cells
Releases Ca+ from sarcoplasmic reticulum
Contraction
Side effects of Digoxin
G.I. toxicity nausea vomiting
Bradycardia
Neurological toxicity‘s
Milrinone moa
Block phosphodiesterase isozyme 3 (PDE-3)
more cAMP (more Ca)
Increased contractility + vasodilation
Adverse effects of milrinone
Arrhythmias
Dabutamine mechanism of action
Increase cAMP
heart—- contraction, vessels relaxation
Dopamine moa
At moderate dose work on B1 receptor to increase contractility
ACE inhibitors MoA
Reduce after load
Produce natriuretic action [by reduceing the effects of elevated renin-
angiotensin system]
Prevent/reverse cardiac remodeling
Beta blocker in CHF
Block compensatory sympathetic stimulation
Reduces left ventricular mass & size
Aldosterone antagonists effects
effective in inhibiting cardiac hypertrophy and
re-modelling by blocking the affects of aldosterone
