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Pharmacology > NSAIDs > Flashcards

NSAIDs Flashcards

1
Q

NSAIDs classification

A

Non-selective for COX1/2

- irreversible: Aspirin
- Reversible: Acetaminophen, Ibuprofen, Naproxen, 	Diclofenac, indomethacin, Ketorolac

Selective COX2
-Celecoxib, Meloxicam

MgCholineSalicylates

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2
Q

NSAIDs are highly bound to protein..?

A

Albumin

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3
Q

Functions of NSAIDs

A

Anti-Pyretic actions—-| PGE2— reset Temperature

Analgesic effects——-| COX2 —-| PG——| pain

Anti-inflammatory actions ——-| COX2

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4
Q

What drugs are used for Patent ductus arteriosus (PDA) ?

A

Ibuprofen

Indomethacin

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5
Q

SEs of NSAIDs

A

GIT disturbances

Cardiovascular effect (COX2 produce PC a VD)

Renal Insufficiency/Nephropathy

Edema

Hypersensitivity skin reactions.

Bronchospasm (with aspirin)

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6
Q

What NSAID has a decreased risk of GI ulceration

A

Diclofenac [Voltaren]

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7
Q

What NSAID decrease the proliferation of T and B cells

A

Indomethacin

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8
Q

NSAID with no anti-inflammatory activity but very potent analgesic

A

Ketorolac

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9
Q

Management of Acetaminophen toxicity

A

Activated charcoal

N-Acetylcysteine

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Pharmacology (11 decks)

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