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MSK > Vasculitis > Flashcards

Vasculitis Flashcards

1
Q

What is the most common large vessel vasculitis

A

Giant cell arteritis

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2
Q

What are the three types of medium vessel vasculitis

A

Polyarteritis Nodosa
Buergers (Male w/skin necrosis)
Kawasaki (Children w/ Beefy tongue)

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3
Q

What are the three types of Small vessel vasculitis

A

EGPA (pANCA)
GPA(cANCA)
Henloch Schonlen Purpura (IgA)

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4
Q

What is EGPA

A

Eosinophillic Granulomatosis w/ Polyangitis
pANCA

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5
Q

What is GPA

A

Granulomatosis w/Polyangititis (MC)
cANCA
- Cause Glomerulonephritis
- Sx = Saddle shaped nose

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6
Q

What is Henloch Schonlein Purpura

A

IgA Vasculitis

  • IgA deposition at Glomerula BM
  • Sx = Purpuric rash on shins
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7
Q

What is the most likely treatment for vasculitis

A

Corticosteroids

-Consider PPI and Bisphosphonates if CS use is long term

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8
Q

How does GCA present

A

Unilateral temple headache
Jaw claudication
Vision chnages
Tender temporal scalp

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9
Q

What is the pathology of GCA

A

External carotid affected

  • Tender scalp = Temporal branch
  • Vision = Opthalmic branch
  • Jaw = Facial branch
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10
Q

How is GCA Investigated

A 
1st = Raised ESR
Gold = Temporal artery biopsy (Gran. Inflammation of media and intima/ patchy skip lesions)
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11
Q

What does a temporal artery biopsy show in GCA

A

Patchy skip lesions

Granulomatous inflammation of media and intima

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12
Q

How is GCA treated

A

Prednisolone

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13
Q

What is the main complication of GCA

A

Sudden painless unilateral vision loss

  • Temp = Amaurosis Fugax
  • Perm = High Dose IV METHYLPREDNISOLONE
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14
Q

Who is typically affected by Polyarteritis Nodosa

A

Males with Hep B

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15
Q

What are the presentations of Polyarteritis Nodosa

A

Mononeruritis complex (Vasa nervosum ischaemia)
GI bleed
Pre Renal AKI
Skin nodules

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16
Q

How is Polyarteritis Nodosa investigated

A

CT Angiogram = Beads on string aneurysms
Biopsy = Necosing vasculitis

Biopsy = Necrosing vasculitis

17
Q

How is Polyarteritis nodosa treated

A

Corticosteroids
Control HTN w/ ACE-i
Hep B treatment last

18
Q

Why is a large fluid sample taken in a Temporal artery biopsy

A

GCA shows skip lesion

19
Q

If a patient is on long term predinisolone for vaculitis, what should be given

A

PPI - GI
Bisphosphonate - Bone

20
Q

What two arteries are affected in Polyarteritis Nodosa

A

Mesenteric
Renal

21
Q

What is the mononeuritis complex in polyarteritis Nodosa

A

Vasa Nervosum Ischemia

MSK (19 decks)

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