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MSK > Osteoarthritis > Flashcards

Osteoarthritis Flashcards

1
Q

What is Osteoarthritis

A

Non inflammatory degenerative mechanical bone sheering

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2
Q

What are the RF for Osteoarthritis

A

Women 50+
Obesity
Occupation/sports
COL2A1 genetic prredisposition

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3
Q

What is the pathology of Osteoarthritis

A

Imbalanced cartilage breakdown
Chondrocyte metalloproteinase secretion
T2 Collagen is degraded causing cysts
Bone attempts to compensate w/T1 Collagen
Osteophytes are produced and bone becomes remodelled

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4
Q

What enzyme secretion is increased due to Increased cartilage breakdown

A

Chondrocyte metalloproteinase

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5
Q

How does the bone try to overcome Cysts made by Chondrocyte metalloproteinase degradation of T2 Collagen

A

Increases T1 Collagen causing osteophytes and remodelling

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6
Q

What are osteophytes

A

Abnormal bony growths of T1 Collagen

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7
Q

What are the MAIN presentations of Osteoarthritis

A

> 30 min Morning pain worse through day
Bouchard(PIPJ) and Heberden(DIPJ) Nodes
No extraarticular Sx

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8
Q

How can the nodes on the fingers in osteoarthritis be described

A

Asymetrical, hard and non inflamed

Thumb, Big toe, Hip and Knee

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9
Q

What is the LOSS presentation of osteoarthritis on an Xray

A

Loss of joint space
Osteophytes
Subchondral Sclerosis
Subchondral Cysts

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10
Q

How is osteoarthritis investigated

A

Bloods = normal (No inflammation)
X Ray = LOSS

X Ray shows LOSS Sx

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11
Q

How is osteoarthritis treated

A

Lifestyle change
NSAIDs for pain
Arthroplasty (Knee/Hip replacement)

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12
Q

What is the last resort management of osteoarthritis

A

Arthroplasty of knee/hip

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13
Q

What gene is associated w/ Osteoarthritis

A

COL2A1

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14
Q

Where are bouchard nodes found

A

PIP Joints

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15
Q

Where are heberdens nodes found

A

DIP Joints

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16
Q

What triggers T1 Collagen in the pathology of osteoarthritis that results in osteophytes and remodelling

A

Chondrocyte metalloproteinase secretion resulting in T2 degrading and cyst production

17
Q

What collagen degrades to produce cysts in osteoarthritis

A

T2 Collagen

18
Q

When is pain the worst with osteoarthritis

A

30 mins in the morning
Worse with use

19
Q

What pathological feature starts the pathway of osteoarthritis

A

Imbalanced cartilage breakdown

MSK (19 decks)

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