Gout (Negative Needle) Flashcards
What is Gout
Sodium urate crystal deposition in and around joints
what are the RF for Gout
Middle Aged Overweight men
Purine rich food (meat, seafood, Beer)
CKD and Diuretics
what is the pathology of Gout
PURINES into too much URIC ACID into too much MONOSODIUM NITRATE
How is uric acid levels normally controlled
Renal Excretion
What converts Purine into Uric acid
Xanthine Oxidase
What are the presentations of Gout
Monoarticular
Big TOE (Metatarsophelangeal joint)
-Sudden Severe swollen
What is a Differential for gout
Septic arthritis but no crystalarphropathy
How is Gout Investigated
Joint Aspirate w/ Polarised light MS
- Negative Bifringemnet
- Needle shaped crystals
How is Gout treated
Low purine/High dairy diet
NSAIDs then Colchicine then Steroid injection
Allopurinol for prevention
What is the action of Allopurinol
Xanthine Oxidase Inhibitor (Decrease Uric acid)
What Is Pseudogout
Calcium Pyrophosphate crystals deposit along JOINT CAPSULE
Whats the difference between crystal type in gout and pseudogout
Gout = Sodium Urate Pseudo = Calcium pyrophosphate
Who is most commonly affected by pseudogout
Elderly women
What are the RF for Pseudogout
Diabetes
Metabolic disease
Osteoarthritis
How does Pseudogout present
Polyarticular
Swollen Hot red knee joint
