Paget's Disease Flashcards
1
Q
What is Paget’s
A
Osteomitis Deformans
- Disorder of bone remodelling due to decreased osteoblast and increased osteoclast function
- Areas of sclerosis and lysis
2
Q
What are the presentations of paget’s
A
Bone pain
Bowed tibia and skull deformity
CN8 Nerve compression
Hydrocephalus
3
Q
What can compression of the C8 cause in Paget’s
A
Deafness
4
Q
What is Hydrocephalus
A
Blockage of Sylvian Aquaduct
5
Q
How is Paget’s Investigated
A
Xray = Cotton wool skull Urinary Hydroxyproline (protein of bone and collagen) Raised ALP
6
Q
What is cotton wool skull
A
Pagets Sx where there are areas of lysis and sclerosis
7
Q
How is Paget’s treated
A
Bisphosphonates
NSAIDs for Pain