Paget's Disease Flashcards

1
Q

What is Paget’s

A

Osteomitis Deformans

  • Disorder of bone remodelling due to decreased osteoblast and increased osteoclast function
  • Areas of sclerosis and lysis
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2
Q

What are the presentations of paget’s

A

Bone pain
Bowed tibia and skull deformity
CN8 Nerve compression
Hydrocephalus

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3
Q

What can compression of the C8 cause in Paget’s

A

Deafness

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4
Q

What is Hydrocephalus

A

Blockage of Sylvian Aquaduct

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5
Q

How is Paget’s Investigated

A
Xray = Cotton wool skull
Urinary Hydroxyproline (protein of bone and collagen)
Raised ALP
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6
Q

What is cotton wool skull

A

Pagets Sx where there are areas of lysis and sclerosis

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7
Q

How is Paget’s treated

A

Bisphosphonates

NSAIDs for Pain

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