Vancomycin Flashcards
What ABX is pretty much the “gold-standard” for treating any kind of osteomyelitis, endocarditis, or Nosocomial Pneumonia?
Vancomycin
What G+ organisms will Vancomycin cover?
ALL G+
except VRE, AKA vancomycin resistant enterococcus
What is Vancomycin’s mechanism of action?
-Vancomycin inhibits the biosynthesis of peptidoglycan polymers during cell wall formation (complexes with D-ALANYL-D-ALANINE precursor).
Is Vancomycin bactericidal or bacteriostatic?
BACTERIOCIDAL
T/F
Vancomycin exhibits Post Antibiotic Effect?
TRUE
-After exposure to inhibitory concentrations of vancomycin, continued killing occurs (2 hrs).
Why is Vancomycin almost always given IV?
When is it given orally?
Poorly absorbed in GI Tract
C. Difficile infections
T/F
Vancomycin distributes to CSF only with inflammation.
T/F
Vancomycin almost entirely unchanged via glomerular filtration.
TRUE
TRUE
Is there a reason Linezolid should be used over Vancomycin in the case of pneumonias?
NO–data suggesting linezolid penetrated lungs better than Vanc was smoke-and-mirrors
What are the common hematological adverse reaction to Vancomycin?
Eosinophelia
Thrombocytopenia
Neutropenia
What are the common hypersensitive adverse reaction to Vancomycin?
What are the common Local adverse reaction to Vancomycin?
Maculopapular Rash
Thrombophlebitis
Which adverse reactions to Vancomycin are related to dosage?
Ototoxicity (peaks)
Nephrotoxicity (troughs)
Which adverse reactions to Vancomycin are related to speed of infusion?
RED MAN SYNDROME
What bugs are covered by Vancomycin?
ALL G+ (Staph, Strep, Entero)
Clostridium
Bacillus Anthracis
Crynebacteria
Does Vancomycin cover any G– Species?
NO
What are indications that Vancomycin should be used?
Serious B-lactam resistant G+ infections
Patients seriously allergic to B-lactams with G+ infections
Recurrent C. Diff
Metronidazole resistant C. Diff
