Tetracyclines

Question 1

What are the 6 memebers of the Tetracyclines?

Answer 1

• Doxycycline
• Minocycline
• Demeclocycline
• Oxytetracycline
• Chlortetracycline
• Tetracycline

Question 2

Are Tetracyclines Bacteriocidal or Bacteriostatic?

Answer 2

BACTERIOSTATIC

Question 3

What is the Tetracycline mechanism of action?

Answer 3

Reversibly binds to 30S ribosomal subunit to decreasesprotein synthesis

Question 4

Why would you advise a patient not to eat or take a vitamin or iron before a dose of a tetracycline?

Answer 4

Absorption decreased by food

drug is bound up by cations just like fluoroquinolones

Question 5

Which Tetracyclines are RENALLY eliminated?

Answer 5

• Tetracycline
• Oxytetracycline
• Demeclocycline

Question 6

Which Tetracyclines are HEPATICALLY eliminated?

Answer 6

• Doxycycline

* Minocycline

Question 7

Fluoroquinolones aren’t to be given to kids below 18 for risk of tendon ruptures. Why aren’t you to give tetracyclines to kids under the age of 8?

Answer 7

Discoloration of Developing Teeth

Question 8

What adverse reaction do tetracyclines have in common with fluoroquinolones that has to do with the sun?

Answer 8

PHOTOSENSITIVITY

Question 9

Why can Demeclocycline be used to help treat SIADH?

Answer 9

Reversible diabetes insipidus associated with Demeclocycline

Question 10

Why must you NEVER take Tetracycline after its expiration date?

Answer 10

Fanconi-like Syndrome (N/V, lethargy, polydipsia, polyuria, proteinuria, acidosis, hypokalemia)
• Use of outdated citric acid formulation of Tetracycline (no longer available)

Question 11

Which Tetracycline is associated with the following adverse effects:
Dizziness, Ataxia, Vertigo

Answer 11

Minocycline

Question 12

Why must you be careful prescribing a tetracycline to a pt. on Warfarin?

Answer 12

Enhances anticoagulation of Warfarin

monitor prothrombin time

Question 13

Why must you be careful prescribing a tetracycline as well as anything bacteriocidal to a pt.?

Answer 13

Potential antagonism effect since these agetns are static and many cidal agents require active growth

Question 14

What bugs are covered by Tetracyclines?

Answer 14

• Gram Positive (Staph, Strep)
• Gram Negative (H.flu, Neisseria)
• Atypicals
• Rickettsia

Question 15

What causes Rocky Mountain spotted fever?

How would you treat it?

Answer 15

Rikettsia Infections (parasites)

Tetracyclines

Question 16

Could Tetracyclines be used to treat:
• Mycoplasma pneumonia 
• Chlamydia infections
• Urogenital
• Acne

Answer 16

YAS

Question 17

What are the only 3 types of antibiotics that cover atypicals?

Answer 17

• Macrolides
• Tetracyclines
• Fluoroquinolones

Question 18

Instead of the 7day doxycycline for chlamydia, what non-tetracycline can you take all at once for treatment that is kind of harsh on the stomach this way?

Answer 18

Azithromycin (whole Z pack all at once)

Question 19

Besides tetracyclines, what else can be used to treat H. Pylori?

Answer 19

Clarithromycin, quinolones

Question 20

How do you treat Brucellosis (Unpasteurized cheeses, milk cause fever, sweats, headaches, back pains, and malaise)?

Answer 20

Tetracycline + Gentamicin

Question 21

How do you treat Vibrio cholera/vulnificus?

Answer 21

Tetracyclines

Question 22

How do you treat Borrelia burgdorferi (Lyme disease, flu like symptoms)?

Answer 22

Tetracyclines

Question 23

What is the ONLY Tetracycline used for Na+ retention in the instance of SIADH?

Answer 23

Demeclocycline

Question 24

Tetracyclines Take Home Points

• Do not use in Pregnancy/kids

Answer 24

Tetracyclines Take Home Points

• Do not use in Pregnancy/kids