Quinupristin/Dalfopristin (Synercid)

Question 1

Is “Synercid” (Quinupristin/Dalfopristin) bacteriocidal or bacteriostatic?

Answer 1

Synercid, the combination of Quinupristin/Dalfopristin is BACTERIOCIDAL

Quinupristin itself alone and Dalfopristin itself alone are BACTERIOSTATIC

Question 2

What is the mechanism of action for Quinupristin/Dalfopristin (Synercid)?

Answer 2

• Irreversibly bind to the 50S bacterial ribosomal subunit
• Quinupristin inhibits chain formation resulting in early termination
• Dalfopristin inhibits peptide elongation by interfering with peptidyltransferase

Question 3

Can you take oral Quinupristin/Dalfopristin (Synercid)?

Answer 3

NO, IV ONLY (PICC line preferred)

Question 4

What G+ bugs are covered by Quinupristin/Dalfopristin (Synercid)?

Answer 4

-Gram+ cocci

Question 5

Other than G+ cocci, what bugs are covered by Quinupristin/Dalfopristin (Synercid)?

Answer 5

• Anaerobes

- Haemophilus influenzae (some G–)

Question 6

What resistant bugs are covered by Quinupristin/Dalfopristin (Synercid)?

Answer 6

• VR Enterococcus FAECIUM
• PCN R Streptococcus pneumoniae
• MR staphylococci

-NOT VR ENTEROCOCCUS FAECALIS

Question 7

Should Quinupristin/Dalfopristin (Synercid) be used to treat G+ or G– bugs?

Answer 7

G+