Clindamycin

Question 1

What is Clindamycin’s mechanism of action?

Answer 1

Binding of 50S ribosome resulting in inhibition of protein synthesis.

Question 2

T/F
Clindamycin has a bioavailability of 90%.

T/F
Food delays absorption of Clindamycin but does not decrease amount of absorption.

Answer 2

TRUE

TRUE

Question 3

Where is Clindamycin metabolized?

Answer 3

The LIVER

Question 4

What bugs does Clindamycin cover?

Answer 4

• Streptococcus
• Staphylococcus
• Bacteroides
• Clostridium
• Peptostreptococcus
• Peptococcus

• Toxoplasmosis (sulfonamide allergy)

Question 5

In general, how would you describe Clindamycin bug coverage?

Answer 5

G+ (except Enterococcus) and Anaerobes

Question 6

What would be an instance where you use Clindamycin rather than sulfonamides to treat Toxoplasmosis?

Answer 6

Sulfa allergy

Question 7

What ABX would you couple with Clindamycin to cover all your bases bug-wise when treating a patient with PCN allergy?

Answer 7

Ciprofloxacin

Question 8

Why is Clindamycin IV dose larger than PO?

Answer 8

different salts

Question 9

What adverse effects are associated with Clindamycin usage?

Answer 9

C. difficile infection

Hepatotoxicity