Linezolid (Zyvox) Flashcards
1
Q
What is the mechanism of action for Linezolid (Zyvox)?
A
-Inhibits protein synthesis; binds to 23 S ribosomal RNA of 50 S subunit
2
Q
T/F
Linezolid (Zyvox) can be given either IV or PO.
T/F Oral Linezolid (Zyvox) is 100% bioavailable.
A
TRUE
TRUE
3
Q
What Bugs are covered by Linezolid (Zyvox)?
A
Same as Quinupristin/Dolfopristin (Synercid®) except ALSO:
VR ENTEROCOCCUS FAECALIS
4
Q
Should Linezolid (Zyvox) be used on G+ or G– bugs?
A
G+ COCCI!
MRSA, VISA, VRE, PCN-resistant Strep pneumo
5
Q
What are the 3 hallmark adverse effects of Linezolid (Zyvox)?
A
- Thrombocytopenia
- Serotonin Storm (Linezolid is a monoamine oxidase inhibitor)
- Superinfection (yeast)
6
Q
Why should you watch co-administration of Linezolid (Zyvox) with SSRI?
A
Serotonin Storm!
