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Exam 9 > Valentovic > Flashcards

Valentovic Flashcards

1
Q

Cholestyramine, colesevelam, and colestipol

A

Bile acid resins

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2
Q

Lowers ONLY cholesterol

A

Bile acid resins

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3
Q

Enhance hepatic conversion of cholesterol to bile acids

A

Bile acid resins

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4
Q

Bile acids have negative feedback on _________, rate limiting enzyme

A

7alpha-hydroxylase

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5
Q

Bile acid resins ______ # of hepatic LDL receptors

A

Increase

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6
Q

Bile acid resins _______ form must be mixed with liquids and taken with a meal

A

Powder

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7
Q

GI side effects most common. Interfere with absorption of fat soluble vitamins and/or drugs. Other drugs must be taken 1 hour before or 4 hours after

A

Bile acid resin

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8
Q

Bile acid resins ____ be used during pregnancy. Safe in children ___ or older

A

Can

6

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9
Q

HMG CoA reductase inhibitors are known as

A

Statins

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10
Q

Statins are ___________ inhibitors and they _____ hepatic LDL receptors

A

Competitive

Increase

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11
Q

All statins lower ______

Atorvastatin and Rosuvastatin also lower _________

A

Cholesterol

Triglycerides

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12
Q

Adversely elevates serum transaminases. Causes muscle weakness, myalgias, and dark brown urine. Associated with elevated CPK

A

Statins

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13
Q

Statins ____ be used in pregnancy/nursing mothers

A

Cannot

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14
Q

Rosuvastatin and Atorvastatin have longest ____ and can be taken at any time of day

A

Half life

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15
Q

Maximum endogenous cholesterol synthesis occurs at

A

Night

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16
Q

Fluvastatin, Lovastatin, and simvastatin have ______ and have to be taken at night

A

Short

17
Q

All statins can be used after _____ years, pravastatin can be used after ______ yrs

A

10

8

18
Q

____ increases Lovastatin absorption

A

Food

19
Q

Food _______ absorption of pravastatin and pitavastatin

A

Decrease

20
Q

Hyperlipidemia
Chol >
LDL >
Triglycerides >

A

240
160
200

21
Q

Lovastatin and simvastatin are

A

Prodrugs

22
Q

Rosuvastatin and fluvastatin

A

CYP2C9

23
Q

Atorvastatin, Lovastatin, and Simvastatin. Avoid grapefruit

A

CYP 3A4

24
Q

Inhibits cholesterol absorption at enterocytes of small intestine.

A

Ezetimibe

25
Q

Reduces cholesterol. When combined with statins, will lower LDL more than high dose statin

A

Ezetimibe

26
Q

Alirocumab and evolocumab are

A

PCSK9 inhibitors

Proprotein convert are subtilisin/Kexin 9

27
Q

Lovastatin and simvastatin are

A

Prodrugs

28
Q

Rosuvastatin and fluvastatin

A

CYP2C9

29
Q

Atorvastatin, Lovastatin, and Simvastatin. Avoid grapefruit

A

CYP 3A4

30
Q

Inhibits cholesterol absorption at enterocytes of small intestine.

A

Ezetimibe

31
Q

Reduces cholesterol. When combined with statins, will lower LDL more than high dose statin

A

Ezetimibe

32
Q

Alirocumab and evolocumab are

A

PCSK9 inhibitors

Proprotein convert are subtilisin/Kexin 9

Exam 9 (12 decks)

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