Valentovic 2

Question 1

Ge fibrosis, fenofibrate, and clofibrate

Answer 1

Fib rates

Question 2

Decrease hepatic VLDL triglyceride production and increase lipoprotein lipase activity

Answer 2

Fibrates

Question 3

Increase Apo I and II expression which increases HDL

Answer 3

Fibrates

Question 4

Use for high triglycerides. Also increase HDL

Answer 4

Fibrates

Question 5

Increased risk of gallstones

Answer 5

Clofibrate

Question 6

Fibrates have increased risk of ___ when combined with a statin. Worst with ____.

Answer 6

Myopathy

Clofibrate

Question 7

Lowers cholesterol. Used with statins. Given subcutaneous injection biweekly or monthly. Hypersensitivity

Answer 7

PCSK9 inhibitors

Question 8

Decrease triglyceride synthesis and lower delivery of FFAs to the liver. Diminish hepatic VLDL and LDL production. Increase lipoprotein lipase activity

Answer 8

Niacin/Nicotinic Acid

Question 9

Lower triglycerides and cholesterol, and increase HDL

Answer 9

Niacin/Nicotinic Acid

Question 10

Can cause flushing, peptic ulcers, itching, hyperdrive is, and worsen glucose intolerance

Answer 10

Niacin/Nicotinic Acid

Question 11

Elevated chylomicrons, triglycerides. Defect in lipoprotein lipase or Apo C. No increased risk of heart disease. Diet therapy critical

Answer 11

Familial lipoprotein lipase deficiency

Question 12

Elevated cholesterol and LDL. Markedly increased risk of CVD. Decreased plasma clearance of LDL

Answer 12

Familial hypercholesterolemia

Question 13

Increased LDL and VLDL

Answer 13

Familial combined hyperlipidemia

Question 14

Elevated cholesterol and triglycerides. Defects in VLDL catabolism cause accumulation of IDL. Most sensitive responders to Fibrates

Answer 14

Dysbetalipoproteinemia

Question 15

Increased triglycerides and VLDL. Worsened by alcohol. Tx with Fibrates

Answer 15

Familial hypertriglyceridemia

Question 16

Elevated chylomicrons and VLDL. Fibrates and Nicotinic acid

Answer 16

Familial mixed hypertriglyceridemia

Question 17

______ levels elevated in biliary disease, diabetes, renal disease, and hypothyroidism

Answer 17

Cholesterol

Question 18

_______ levels elevated in diabetes, renal disease, and alcoholism

Answer 18

Triglycerides

Question 19

______ diuretics increase cholesterol and triglycerides

Answer 19

Thiazides

Question 20

Diminish HDL and elevated triglycerides

Answer 20

Beta blockers

Question 21

Elevate triglycerides

Answer 21

Oral contraceptives

Question 22

Use _________ to treat high cholesterol

Answer 22

Statins

Question 23

With ____, must monitor ALT - myalgia increases with dose.

Answer 23

Statins

Question 24

Does not induce muscle pain, can be combined with statins. Can be used in pregnancy

Answer 24

Ezetimibe

Question 25

Lower cholesterol by 60-70%

Answer 25

PCSK9 inhibitors

Question 26

Original agents to treat high triglycerides

Answer 26

Fibrates

Question 27

Nicotinic acid used to treat

Answer 27

High triglycerides