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Exam 9 > Drugs CHF > Flashcards

Drugs CHF Flashcards

1
Q

Digoxin, dobutamine, and dopamine are positive ionotropic drugs

A

Positive ionotropic activity

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2
Q

Positive ionotropic activity and vasodilator

A

PDE inhibitor

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3
Q

Venodilators decrease preload, which decreases

A

Edema

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4
Q

In CHF

⬇️ TPR > ⬇️ afterload > _____ SV > ____ CO > _____ tissue perfusion

A

Increase

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5
Q

Balanced venous = arterial vasodilation
Balance ⬇️ preload and afterload
Increase CO

A

Nitroprusside

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6
Q

Venodilation mainly

A

Organic nitrates

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7
Q

Low doses > mainly ⬇️ preload which decreases congestion/edema/CO

A

Organic Nitrates

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8
Q

High doses > ⬇️ preload and afterload to maintain CO

A

Organic Nitrates

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9
Q

Decreased mortality when isosorbide dinitrate is combined with

A

Hydralazine

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10
Q

Arteriodilator
Decreased afterload > Increases SV > Increase CO
Decreased mortality when combined with a nitrate

A

Hydralazine

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11
Q

Decrease remodeling and mortality

A

ACEi and ARB

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12
Q

⬇️ afterload > ___ SV > ____ CO

⬇️ LVEDP (venodilation, _____ RAA > _____ salt and water retention)

A

Increase
Decrease
ACEi and ARBs

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13
Q

Increase cAMP in heart > __ contractility

Increase cAMP in vascular smooth muscle > vasodilation

A

PDEi

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14
Q

Increase CO and cause vasodilation

A

PDEi

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15
Q

PDEi used in short term IV treatment of severe refractory CHF

A

Milrinone

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16
Q

Carvedilol, metoprolol, and bisoprolol are

A

Beta blockers

17
Q

Decrease mortality in CHF
Inhibit remodeling
Titrate doses up with monitoring

A

Beta blockers

18
Q

Directly effect the heart to inhibit Na/K ATPase which ___ calcium and ______ contractility

A

Digoxin

Increases

19
Q

Has direct vagomimetic effects to ⬇️ SA node > ⬇️ HR

⬇️AV node conduction > AV block

A

Digoxin

20
Q

Direct effects of digoxin predominate at ___ doses

A

High

21
Q

High doses
Induction of delayed afterdepolarization > tachyarrhythmias
Arrhythmias

A

Digoxin

22
Q

Has renal elimination

A

Digoxin

23
Q

Hydralazine, organic nitrates, and nitroprusside are

A

Vasodilators

Exam 9 (12 decks)

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